1. Secondary metabolites from Aspergillus japonicus CAM231, an endophytic fungus associated with Garcinia preussii.
- Author
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Jouda JB, Fopossi JD, Kengne FM, Djama Mbazoa C, Golz C, Strohmann C, Fogue SK, and Wandji J
- Subjects
- Anti-Bacterial Agents chemistry, Antineoplastic Agents chemistry, Aspergillus chemistry, Breast Neoplasms drug therapy, Breast Neoplasms pathology, Cameroon, Cell Line, Tumor, Crystallography, X-Ray, Drug Evaluation, Preclinical, Endophytes metabolism, Humans, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molecular Structure, Pyrones chemistry, Pyrones metabolism, Secondary Metabolism, Terpenes isolation & purification, Terpenes metabolism, Anti-Bacterial Agents pharmacology, Antineoplastic Agents pharmacology, Aspergillus metabolism, Furans isolation & purification, Garcinia microbiology, Phenols isolation & purification, Pyrones isolation & purification
- Abstract
Chemical investigation of Aspergillus japonicus CAM231, isolated from the leaf of Garcina preussii collected in Cameroon, yielded two new compounds; one pyrone derivative, hydroxy neovasinin (1) and one phenol derivative, asperolan (2), together with two known compounds neovasifurarone B (3) and variecolin (4). The structures of the two new compounds were established using intensive NMR spectroscopy and HRMS spectra in comparison with data found in literature. The structure of compound 1 was confirmed by single-crystal X-ray crystallographic analysis in combination with NOESY experiment. The new compounds were screened for their cytotoxic and antibacterial properties; however, the tested compounds displayed no significant activities.
- Published
- 2017
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