1. SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children
- Author
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Carla Mastrorilli, Carlo Caffarelli, Stefania Arasi, Silvia Caimmi, Umberto Pelosi, Fabrizio Franceschini, Francesca Mori, Gian Luigi Marseglia, Dora Di Mauro, Lucia Diaferio, Paolo Bottau, Simona Barni, Pasquale Comberiati, Fabio Cardinale, Davide Caimmi, Lucia Liotti, Marzia Duse, Giuseppe Crisafulli, Francesca Saretta, and Francesco Paravati
- Subjects
Drug ,medicine.medical_specialty ,Allergy ,medicine.drug_class ,media_common.quotation_subject ,Provocation test ,Drug allergy ,Antibiotics ,Review ,medicine.disease_cause ,Drug Hypersensitivity ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,Internal medicine ,Diagnosis ,medicine ,Humans ,030212 general & internal medicine ,drug hypersensitivity reactions ,Challenge ,allergy ,antibiotics ,challenge ,children ,diagnosis ,drug allergy ,nonsteroidal anti-inflammatory drugs ,pediatric ,Child ,Children ,media_common ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,lcsh:RJ1-570 ,lcsh:Pediatrics ,Gold standard (test) ,medicine.disease ,Drug hypersensitivity reactions ,Non-steroidal anti-inflammatory drugs ,Pediatric ,Anti-Bacterial Agents ,030228 respiratory system ,Position paper ,business - Abstract
Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Different protocols through the administration of divided increasing doses have been postulated according to the type of drug and the onset of the reaction (immediate or non immediate reactions). DPT protocols differ in doses and time interval between doses. In this position paper, the Italian Pediatric Society for Allergy and Immunology provides a practical guide for provocation test to antibiotics and NSAIDs in children and adolescents.
- Published
- 2018