1. Ischemia- and reperfusion-induced arrhythmias are prevented by putrescine.
- Author
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Tagliavini S, Genedani S, Bertolini A, and Bazzani C
- Subjects
- Anesthesia, Animals, Arrhythmias, Cardiac etiology, Arrhythmias, Cardiac physiopathology, Coronary Vessels physiology, Male, Rats, Rats, Inbred Strains, Anti-Arrhythmia Agents, Arrhythmias, Cardiac prevention & control, Coronary Disease complications, Myocardial Reperfusion, Putrescine pharmacology
- Abstract
The influence of putrescine on cardiac arrhythmias induced by either permanent ligature of the left anterior coronary artery or heart reperfusion following a 5-min coronary occlusion was studied in anesthetized rats. Reperfusion-induced arrhythmias were significantly prevented by the i.v. injection of 150-200 mg/kg of putrescine, the survival rate being 100% in treated animals and 40% in controls. At a dose level of 200-300 mg/kg i.v., putrescine also significantly reduced the duration of ventricular tachycardia induced by permanent coronary occlusion. These findings show that putrescine significantly reduces the consequences of cardiac ischemia and reperfusion, probably as a consequence of its multiple stabilizing effects at the membrane level.
- Published
- 1991
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