1. On the antiarrhythmic activity of one N-substituted piperazine derivative of trans-2-amino-3-hydroxy-1, 2, 3, 4-tetrahydroanaphthalene.
- Author
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Staneva-Stoycheva D, Boyadjiev T, Raynova L, Mihaylova S, and Tomov T
- Subjects
- 2-Naphthylamine analogs & derivatives, Adrenergic beta-Antagonists, Animals, Cats, Erythrocyte Membrane drug effects, Humans, In Vitro Techniques, Microsomes, Liver metabolism, Oxidative Phosphorylation drug effects, Rabbits, Rats, Time Factors, 2-Naphthylamine pharmacology, Anti-Arrhythmia Agents, Naphthalenes pharmacology
- Abstract
The antiarrhythmic activity of the compound N-(trans-3-hydroxy-1,2,3,4-tetrahydro-2-naphthyl)-N-(3-oxo-3-phenyl-2-methylpropyl)-piperazine hydrochloride, referred to as P11, is studied on anaesthesized cats and Wistar albino rats, as well as on non-anaesthesized rabbits. Four types of experimental arrhythmia are used--with BaCl2, with chloroform-adrenaline, with strophantine G and with aconitine. The compound P11 is introduced in doses of 0.25 and 0.50 mg/kg intravenously and 10 mg/kg orally. The compound manifests antiarrhythmic activity in all models of experimental arrhythmia used, causing greatest inhibition on the arrhythmia induced by chloroform-adrenaline (in 90 per cent) and with BaCl2 (in 84 per cent). The results obtained are associated with the beta-adrenoblocking and with the membrane-stabilizing action of the compound.
- Published
- 1979