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Your search keyword '"Engelhardt EL"' showing total 2 results
Start Over Author "Engelhardt EL" Topic anti-arrhythmia agents
2 results on '"Engelhardt EL"'

1. 2-, 3-, and 4-(alpha, alpha, beta, beta-tetrafluorophenethyl)benzylamines. A new class of antiarrhythmic agents.

Author

Christy ME, Colton CD, Mackay M, Staas WH, Wong JB, Engelhardt EL, Torchiana M, and Stone CA

Subjects
Animals, Benzylamines pharmacology, Dogs, Electrocardiography, Heart Rate drug effects, Methods, Structure-Activity Relationship, Amines chemical synthesis, Anti-Arrhythmia Agents chemical synthesis, Benzylamines chemical synthesis
Published
1977
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2. Antiarrhythmic agents. 2-, 3-, And 4-substituted benzylamines.

Author

Remy DC, Van Saun WA Jr, and Engelhardt EL

Subjects
Amines pharmacology, Animals, Anti-Arrhythmia Agents pharmacology, Benzyl Compounds pharmacology, Blood Pressure drug effects, Dogs, Electrocardiography, Heart Rate drug effects, Myocardial Infarction physiopathology, Structure-Activity Relationship, Ventricular Fibrillation physiopathology, Amines chemical synthesis, Anti-Arrhythmia Agents chemical synthesis, Benzyl Compounds chemical synthesis
Abstract

The synthesis of a series of 2-, 3-, and 4-substituted benzylamine derivatives is described. These compounds were studied for their effect on experimental cardiac arrhythmias. Many of the derivatives, but in particular 2-(p-methoxyphenylethynyl)benzylamine (3d), alpha,alpha-dimethyl-4y(phenylethynyl)benzylamine (7a), and alpha,alpha-dimethyl-4-phenethylbenzylamine (12g), showed good antiarrhythmic activity.

Published
1975
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