1. Morindaquinone, a new bianthraquinone from Morinda coreia roots.
- Author
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Chokchaisiri S, Siriwattanasathien Y, Thongbamrer C, Suksamrarn A, and Rukachaisirikul T
- Subjects
- Anthraquinones chemistry, Anthraquinones isolation & purification, Breast Neoplasms metabolism, Humans, MCF-7 Cells drug effects, Anthraquinones pharmacology, Breast Neoplasms chemistry, Morinda, Plant Roots chemistry
- Abstract
Phytochemical investigation of the roots of Morinda coreia led to the isolation of one new bianthraquinone, morindaquinone ( 1 ), together with 12 known compounds, soranjidiol ( 2 ), rubiadin-1-methyl ether ( 3 ), 2-methoxy-1,3,6-trihydroxyanthraquinone ( 4 ), 1-hydroxy-2-methylanthraquinone ( 5 ), tectoquinone ( 6 ), nordamnacanthal ( 7 ), damnacanthal ( 8 ), 2-formylanthraquinone ( 9 ), 3-hydroxy-2-hydroxymethylanthraquinone ( 10 ), lucidin-ω-methyl ether ( 11 ), scopoletin ( 12 ) and (+)-mellein ( 13 ). The structures of these compounds were determined on the basis of extensive spectroscopic analyses, as well as by comparison with literature reports. Compound 1 was the first example of bianthraquinone found in the genus Morinda , whereas compound 13 was firstly isolated from this genus. Among them, compounds 2 , 7 , 8 and 10 exhibited moderate to weak cytotoxicity against human cervical (HeLa), human colon (HT 29) and human breast (MCF-7) cell lines, while compounds 6 and 9 - 11 showed weak anti-acetylcholinesterase activity.
- Published
- 2021
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