1. Antimalarial Activity of the Chemical Constituents of the Leaf Latex of Aloe pulcherrima Gilbert and Sebsebe.
- Author
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Teka T, Bisrat D, Yeshak MY, and Asres K
- Subjects
- Animals, Anthracenes chemistry, Anthracenes isolation & purification, Anthracenes pharmacology, Antimalarials chemistry, Antimalarials isolation & purification, Antimalarials pharmacology, Disease Models, Animal, Ethiopia, Latex chemistry, Medicine, Traditional, Mice, Molecular Structure, Plant Extracts administration & dosage, Plant Extracts pharmacology, Plant Leaves chemistry, Plasmodium berghei drug effects, Aloe chemistry, Anthracenes administration & dosage, Antimalarials administration & dosage, Malaria drug therapy, Parasitemia drug therapy, Plant Extracts chemistry
- Abstract
Malaria is one of the three major global public health threats due to a wide spread resistance of the parasites to the standard antimalarial drugs. Considering this growing problem, the ethnomedicinal approach in the search for new antimalarial drugs from plant sources has proven to be more effective and inexpensive. The leaves of Aloe pulcherrima Gilbert and Sebsebe, an endemic Ethiopian plant, are locally used for the treatment of malaria and other infectious diseases. Application of the leaf latex of A. pulcherrima on preparative silica gel TLC led to the isolation of two C -glycosylated anthrones, identified as nataloin ( 1 ) and 7-hydroxyaloin ( 2 ) by spectroscopic techniques (UV, IR, ¹H- and
13 C-NMR, HR-ESIMS). Both the latex and isolated compounds displayed antimalarial activity in a dose-independent manner using a four-day suppressive test, with the highest percent suppression of 56.2% achieved at 200 mg/kg/day for 2 . The results indicate that both the leaf latex of A. pulcherrima and its two major constituents are endowed with antiplasmodial activities, which support the traditional use of the leaves of the plant for the treatment of malaria.- Published
- 2016
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