Author: "Robins, Allan" / Topic: anthozoa - Searchworks@Jio Institute Digital Library Search Results

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Author: Meginley RJ, Gupta P, Schulz TC, McLean AB, Robins AJ, and West LM
Subjects: Animals, Diterpenes isolation & purification, Embryonic Stem Cells metabolism, Esters isolation & purification, Florida, Humans, Spectrum Analysis, Anthozoa chemistry, Diterpenes pharmacology, Embryonic Stem Cells drug effects, Esters pharmacology
Abstract: Two new briarane diterpenoids briareolate esters J (1) and K (2) were isolated from the methanolic extract of the octocoral Briareum asbestinum collected off the coast of Boca Raton, Florida. The structures of briaranes 1 and 2 were elucidated by interpretation of spectroscopic data. Briareolate ester K (2) showed weak growth inhibition activity against human embryonic stem cells (BG02).
Published: 2012
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Author: Gupta P, Sharma U, Schulz TC, Sherrer ES, McLean AB, Robins AJ, and West LM
Subjects: Animals, Biological Products chemistry, Biological Products isolation & purification, Cell Line, Diterpenes isolation & purification, Humans, Models, Molecular, Molecular Structure, Anthozoa chemistry, Diterpenes chemistry
Abstract: Three new briarane diterpenoids, briareolate esters L-N (1-3), have been isolated from a gorgonian Briareum asbestinum. Briareolate esters L (1) and M (2) are the first natural products possessing a 10-membered macrocyclic ring with a (E,Z)-dieneone and exhibit growth inhibition activity against both human embryonic stem cells (BG02) and a pancreatic cancer cell line (BxPC-3). Briareolate ester L (1) was found to contain a "spring-loaded" (E,Z)-dieneone Michael acceptor group that can form a reversible covalent bond to model sulfur-based nucleophiles., (© 2011 American Chemical Society)
Published: 2011
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