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Purpose: Graft healing following anterior cruciate ligament (ACL) reconstruction is a complex process characterized by phases of healing that lead to ACL remodelling. Our hypothesis is that fibrin clot addition to ACL reconstruction will result in advanced graft remodelling and healing when compared to a control group at 12 weeks as observed by histology, immunohistochemistry and magnetic resonance imaging (MRI)., Methods: Eleven Spanish Boar goats underwent double-bundle ACL reconstruction: 8 were analysed and 3 were excluded. Group 1 was treated with DB ACL reconstruction utilizing autologous fibrin clots (n = 4), and group 2 was treated with standard DB ACL-R (n = 4). Histological and radiographic analysis was performed at 12 weeks. Each animal underwent 3-T MRI immediately after euthanization for evaluation of graft signal intensity utilizing the signal noise quotient (SNQ). Specimens were then sectioned and stored for standard histological and immunohistochemistry testing., Results: The mean ligament tissue maturity index score was significantly higher for group 1 (15 ± 2.3) compared with group 2 (7.7 ± 5.2) (p < 0.05). The mean vascularity (cell/mm(2)) for group 1 was 7.1 ± 1.3 and 9.3 ± 3.1 for group 2 (n.s.). The mean collagen type 1 (% 50× field) for group 1 was 35.8 ± 22.1 and 19.9 ± 20.5 for group 2 (n.s.). The mean SNQ for the AM bundle was 1.1 ± 0.7 for group 1 and 3.1 ± 1.8 for group 2 (n.s.). The mean SNQ for the total PL bundle was significantly lower for group 1 (1.1 ± 0.7) compared with group 2 (3.7 ± 1.3) (p < 0.05). There was a significant correlation between the vascularity and the ligament tissue maturity index score as well as between collagen type 1 and SNQ, both AM and PL bundles (p < 0.05)., Conclusion: The use of fibrin clot in ACL reconstruction in a caprine model demonstrated improved healing with respect to histological analysis of the intra-articular ACL reconstruction segment and decreased signal intensity on MRI. It may lead to improved graft healing and maturation. By accelerating the intra-articular healing and ligamentization, the outcome of patients after ACL-R can be improved with faster return to sports and daily activity.

Background: Anterior cruciate ligament (ACL) reconstruction is one of the most frequently performed orthopaedic procedures. Failures are a reality of surgery; to limit failures, we must first understand and quantify them., Purpose: The purposes of this study were to determine the rate and factors associated with graft failure after anatomic ACL reconstruction performed with allograft., Study Design: Case series; Level of evidence, 4., Methods: All consecutive subjects who underwent anatomic single- or double-bundle ACL reconstruction with allograft between January 2007 and December 2009 were included and followed clinically. Graft failure was defined as patient-reported instability, pathological laxity during the physical examination, or evidence of a failed graft on magnetic resonance imaging or during arthroscopy. Potential predictors of graft failure that were explored included subject age, sex, height, weight, body mass index, meniscus injury, and time of return to preinjury sports., Results: There were 206 subjects included in this study: 168 double-bundle and 38 single-bundle reconstructions. Overall, 27 (13%) subjects experienced graft failure. Twenty-three (13%) double-bundle subjects failed. The characteristics associated with double-bundle graft failure were younger age (19 vs 25 years, P < .001) and earlier return to sports (at 222 vs 267 days, P = .007). Four (11%) of the single-bundle subjects failed. The characteristics associated with single-bundle graft failure were younger age (19 vs 24 years, P = .049) and increased body mass (83 vs 65 kg, P = .031)., Conclusion: The overall graft failure rate after anatomic ACL reconstruction with allograft was 13%. Younger age, earlier return to sports, and a higher body weight were associated with graft failure.

Background: A goal of anatomic anterior cruciate ligament (ACL) reconstruction should be to create a femoral tunnel aperture that resembles the native attachment site in terms of size and orientation. Aperture morphology varies as a function of the drill-bit diameter, the angle in the horizontal plane at which the drilled tunnel intersects the lateral notch wall (transverse drill angle), and the angle of knee flexion in the vertical plane during drilling., Methods: A literature search was conducted to determine population-based dimensions of the femoral ACL footprint. The tunnel aperture length, width, and area associated with the use of different drill-bit diameters and transverse drill angles were calculated. The effect of the knee flexion angle on the orientation (anteroposterior and proximodistal dimension) and size of the femoral tunnel aperture relative to the native femoral insertion of the ACL were calculated with use of geometric mathematical models., Results: The literature search revealed an average femoral insertion site size of 8.9 mm for width, 16.3 mm for length, and 136.0 mm2 for area. The use of a 9-mm drill bit at a transverse drill angle of 40° resulted in a tunnel aperture area of 99.0 mm2 and a tunnel aperture length of 14.0 mm. Decreasing the transverse drill angle from 60° to 20° led to an increase of 152.9% in length and of 153.1% in tunnel aperture area. When a 9-mm drill bit and a transverse drill angle of 40° were used, the aperture seemed to best match the native ACL footprint when drilling was performed at a knee flexion angle of 102°; deviations from this angle in either direction resulted in increasing tunnel area mismatch compared with the baseline aperture. Increasing the knee flexion angle to 130° decreased the proximodistal dimension of the aperture by 2.78 mm and increased the anteroposterior distance by 0.65 mm, creating a mismatched area of 13.5%., Conclusions: The drill-bit diameter, transverse drill angle, and knee flexion angle can all affect femoral tunnel aperture morphology in medial portal drilling during ACL reconstruction. The relationship between drilling orientation and aperture morphology is critical knowledge for surgeons performing ACL reconstruction.