1. [Antitoxic features of magnesium oxide under combined radiation and thermal injury].
- Author
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Nesterenko VS, Budagov RS, Iatsenko EM, Makarov GF, and Chureeva LN
- Subjects
- Animals, Male, Rats, Rats, Wistar, Shock, Traumatic drug therapy, Antacids administration & dosage, Anti-Bacterial Agents, Drug Therapy, Combination administration & dosage, Heat Stress Disorders, Magnesium Oxide administration & dosage, Radiation Injuries, Experimental drug therapy
- Abstract
Male Wistar rats were exposed to 7.5 Gy total body gamma radiation followed to the additional full-thickness thermal bum. It was shown, that single administration of magnesium oxide in 1 hour after combined injury significantly corrected the early signs of endogenous intoxication. The level of bacterial endotoxemia decreased as well as serum concentration of toxic oligopeptides; general blood serum toxicity has been reduced too. Four-fold magnesium oxide's using as an enterosorbent in combination with antibiotics (doxycyclini, gentamicini or ciprofloxacin) has ensured 73-100% rats survival. All untreated animals dead within 30 days after combined injury.
- Published
- 1998