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Start Over Author "Gonzalez-Fernandez, M" Topic ankylosing spondylitis
2 results on '"Gonzalez-Fernandez, M"'

1. Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project

Author

Garcia-Gomez, C, Martin-Martinez, M, Fernandez C, Castaneda, S, Gonzalez-Juanatey, C, Sanchez-Alonso, F, Gonzalez-Fernandez, M, Sanmarti, R, Garcia-Vadillo, J, Fernandez-Gutierrez, B, Garcia-Arias, M, Manero, F, Senabre, J, Rueda-Cid, A, Ros-Exposito, S, Pina-Salvador, J, Erra-Duran, A, Moller-Parera, I, Llorca, J, Gonzalez-Gay, M, Gonzalez de Rabago, E, Blanco Morales, E, Fernandez Lopez, J, Oreiro Villar, N, Atanes Sandoval, A, Blanco Garcia, F, Alegre De Miquel, C, Gonzalez Fernandez, M, Huguet Codina, R, Yoldi, B, Ramentol, M, Avila, G, Marsal Barril, S, Steiner, M, Munoz, S, Gamero, F, Garcia Toron, J, Moreno Gil, M, Mas, A, Espino, P, Ros, I, Ibanez, M, Murillo, C, Piqueras, J, Berman, H, Cabrera, S, Ruiz, V, Fontsere Paton, O, Fernandez Gutierrez, B, Abasolo, L, Fabregas, M, Romera Baures, M, Nolla, J, Gonzalez-Alvaro, I, Tomero Muriel, E, Garcia de Vicuna, R, Fernandez Nebro, A, Belmonte Lopez, M, Urena, I, Irigoyen, M, Coret Cagigal, V, Lopez Gonzalez, R, Pielfort Garrido, D, Sampedro Alvarez, J, Garcia Aparicio, A, Belmonte Gomez, R, Granados Bautista, P, Hernandez Sanz, A, Sanchez Gonzalez, C, Bachiller, J, Zea, A, Jimenez Zorzo, F, Gimenez Ubeda, E, Marzo Gracia, J, Beltran Audera, C, Medrano, M, Pecondon, A, Erausquin, C, Ojeda, S, Carlos Quevedo, J, Francisco, F, Rodriguez Lozano, C, Babio Herraez, J, Lopez Longo, F, Gerona, D, Gonzalez Fernandez, C, Carreno, L, Monteagudo, I, del Pino, J, Sanchez Gonzalez, M, Corrales, A, Enriqueta Peiro, M, Rosas, J, Rotes, I, Moreno, E, Erra, A, Grado, D, Calvo, J, Rueda, A, Moller, I, Rodriguez, I, Barbadillo, C, Raya, E, Morales, P, Nieto, A, Jimenez, I, Magro, C, Ruibal Escribano, A, Ros Exposito, S, Sanchez Nievas, G, Judez Navarro, E, Sianes Fernandez, M, Garcia Morales, M, Labiano Bastero, I, Consuegra, G, Palmou, N, Martinez Pardo, S, Pujol, M, Riera Alonso, E, Salvador, G, Gonzalez Alvarez, B, Cantabrana, A, Bustabad, S, Delgado, E, Munoz, A, Rodriguez Montero, S, Maria Jimenez, L, Rivera Redondo, J, Gonzalez Hernandez, T, Gonzalez Polo, F, Menor Almagro, R, Moreno, J, Giner Serret, E, Lannuzzelli Barroso, C, Cebrian Mendez, L, Teresa Navio, M, Fernandez Carballido, C, Pagan, E, Mesa del Castillo, P, Naredo, E, Cruz, A, Turrion, A, Mateo, I, Sanchez, J, Galindo, M, Garcia Gonzalez, J, Collantes, E, Ruiz, D, Font, P, Bonilla, G, Lopez Meseguer, A, Moreno, M, Moreno Martinez, M, Beteta Fernandez, M, Linares, L, Morcillo, M, Gonzalez Gomez, M, Aramburu, J, Rivera, N, Fernandez Berrizbeitia, O, Garcia Vivar, M, Riera, M, Maria Leon, Y, Maymo, J, Amirall, M, Iniesta Escolano, S, Sanchez Serrano, S, Lis Bona, M, Fiter, J, Fernandez Melon, J, Espadaler, L, Maiz, O, Belzunegui, J, Banegil, I, Diaz, C, Valls, R, Castellvi, I, Bonet, M, Moreno Ruzafa, E, Calvo Alen, J, Perez Sandoval, T, Revuelta Evrard, E, Godo, J, Fernandez Espartero, C, Navarro Blasco, F, Antonio Gonzalez, J, Miranda-Filloy, J, and CARMA Project Collaborative Grp

Subjects
musculoskeletal diseases, psoriatic arthritis, lipids, stomatognathic diseases, cardiovascular disease, lipoprotein(a), ankylosing spondylitis, spondyloarthritis
Abstract

Objective Cardiovascular (CV) disease is one of the main causes of morbi-mortality in spondyloarthritis (SpA), partially explained by traditional CV risk factors. Information on lipoprotein(a) [Lp(a)], a non-conventional risk factor, in SpA is scarce. In this study we assessed the prevalence of hyperlipoproteinaemia(a) in SpA patients and analysed the possible related factors. Methods A baseline analysis was made of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients and controls included in the CARMA project (CARdiovascular in RheuMAtology), a 10-year prospective study evaluating the risk of CV events in chronic inflammatory rheumatic diseases. A multivariate logistic regression model was performed using hyperlipoproteinaemia( a) (Lp(a) >50 mg/dl) as a dependent variable and adjusting for confounding factors. Results 19.2% (95% CI: 16.80-22.05) of the SpA patients [20.7% (95% CI: 16.91-24.82) of those with AS and 17.7% (95% CI: 14.15-21.75) of those with PsA] and 16.7% (95% CI: 13.23-20.86) of the controls had hyperlipoproteinaemia(a) (p=0.326). Adjusting for age and sex, SpA patients were more likely to have hyperlipoproteinaemia(a) than controls (OR: 1.43, 95% CI: 1.00-2.04; p=0.05), especially those with AS (OR: 1.81, 95% CI: 1.18-2.77; p=0.007). In the adjusted model, apolipoprotein B in all patients, non-steroidal anti-inflammatory drugs in AS, and female sex in PsA, were associated with hyperlipoproteinaemia(a). No disease-specific factors associated with hyperlipoproteinaemia(a) were identified. Conclusion SpA patients show a moderately increased risk of hyperlipoproteinaemia(a) compared to controls, especially those with AS. Lp(a) determination may be of interest to improve the CV risk assessment in SpA patients.

Published
2019

2. Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project

Author

Garcia-Gomez, C., Martin-Martinez, M. A., Fernandez-Carballido, C., Castaneda, S., Gonzalez-Juanatey, C., Sanchez-Alonso, F., Gonzalez-Fernandez, M. J., Sanmarti, R., Garcia-Vadillo, J. A., Fernandez-Gutierrez, B., Garcia-Arias, M., Manero, F. J., Senabre, J. M., Rueda-Cid, A., Ros-Exposito, S., Pina-Salvador, J. M., Erra-Duran, A., Moller-Parera, I., Llorca, J., Gonzalez-Gay, M. A., Gonzalez Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernandez Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco Garcia, Francisco J., Alegre Miquel, Cayetano, Gonzalez Fernandez, Maria J., Huguet Codina, Ramon, Yoldi, Beatriz, Ramentol, Mercedes, Avila, Gabriela, Marsal Barril, Sara, Steiner, Martina, Munoz, Santiago, Gamero, Fernando, Garcia Toron, Jose, Moreno Gil, Maria P., Mas, Antonio J., Espino, Pilar, Ros, Inmaculada, Ibanez, Monica, Murillo, Claudia, Piqueras, Jose A., Sanmarti, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Fontsere Paton, Oscar, Fernandez Gutierrez, Benjamin, Abasolo, Lydia, Fabregas, Maria D., Romera Baures, Montserrat, Nolla, Joan M., Gonzalez-Alvaro, Isidoro, Tomero Muriel, Eva G., Garcia Vicuna, Rosario, Fernandez Nebro, Antonio, Belmonte Lopez, Maria Angeles, Urena, Inmaculada, Irigoyen, Maria V., Coret Cagigal, Virginia, Lopez Gonzalez, Ruth, Pielfort Garrido, Daniel, Sampedro Alvarez, Juana, Garcia Aparicio, Angel Maria, Belmonte Gomez, Rebeca, Granados Bautista, Pastora, Hernandez Sanz, Azucena, Sanchez Gonzalez, Carmen O., Bachiller, Javier, Zea, Antonio, Manero, Francisco J., Jimenez Zorzo, Fernando, Gimenez Ubeda, Eugenio, Marzo Gracia, Jesus, Beltran Audera, Chesus, Medrano, Marta, Pecondon, Angela, Erausquin, Celia, Ojeda, Soledad, Carlos Quevedo, Juan, Francisco, Felix, Rodriguez Lozano, Carlos, Babio Herraez, Jesus, Lopez Longo, Francisco J., Gerona, Delia, Gonzalez Fernandez, Carlos, Carreno, Luis, Monteagudo, Indalecio, Del Pino, Javier, Sanchez Gonzalez, Maria Dolores, Corrales, Alfonso, Enriqueta Peiro, Maria, Senabre, Jose M., Rosas, Jose C., Rotes, Isabel, Moreno, Estefania, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Moller, Ingrid, Rodriguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jimenez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Ros Exposito, Sergio, Sanchez Nievas, Gines, Judez Navarro, Enrique, Sianes Fernandez, Manuela, Garcia Morales, Maria Angeles, Labiano Bastero, Isabel, Consuegra, Gloria, Palmou, Natalia, Martinez Pardo, Silvia, Pujol, Manel, Riera Alonso, Elena, Salvador, Georgina, Gonzalez Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Alejandro Muñoz-Jiménez, Rodriguez Montero, Sergio, Maria Jimenez, Luis, Rivera Redondo, Javier, Gonzalez Hernandez, Teresa, Gonzalez Polo, Francisco J., Menor Almagro, Raul, Moreno, Jose M., Giner Serret, Emilio, Lannuzzelli Barroso, Carla, Cebrian Mendez, Laura, Teresa Navio, Maria, Fernandez Carballido, Cristina, Pagan, Encarnacion, Mesa Del Castillo, Pablo, Naredo, Esperanza, Cruz, Ana, Turrion, Ana, Mateo, Isabel, Sanchez, Julio, Galindo, Maria, Garcia Gonzalez, Javier, Collantes, Eduardo, Ruiz, Desiree, Font, Pilar, Bonilla, Gema, Lopez Meseguer, Antonio, Moreno, Manuel J., Moreno Martinez, Ma Jose, Beteta Fernandez, Ma Dolores, Linares, Luis F., Morcillo, Mercedes, Gonzalez Gomez, Maria L., Aramburu, Jose M., Rivera, Natalia A., Fernandez Berrizbeitia, Olaia, Garcia Vivar, Maria Luz, Riera, Manel, Maria Leon, Yolanda, Maymo, Joan, Amirall, Miriam, Iniesta Escolano, Silvia, Sanchez Serrano, Silvia, Lis Bona, Maria Pilar, Fiter, Jordi, Fernandez Melon, Julia, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquin, Banegil, Inmaculada, Diaz, Cesar, Valls, Ramon, Castellvi, Ivan, Bonet, Maria, Moreno Ruzafa, Estefania, Calvo Alen, Jaime, Perez Sandoval, Trinidad, Revuelta Evrard, Eva, Godo, Javier R., Fernandez Espartero, Cruz, Navarro Blasco, Francisco J., Antonio Gonzalez, Jose, and Miranda-Filloy, Jose A.

Subjects
psoriatic arthritis, lipids, cardiovascular disease, lipoprotein(a), ankylosing spondylitis, spondyloarthritis
Abstract

Objective Cardiovascular (CV) disease is one of the main causes of morbi-mortality in spondyloarthritis (SpA), partially explained by traditional CV risk factors. Information on lipoprotein(a) [Lp(a)], a non-conventional risk factor, in SpA is scarce. In this study we assessed the prevalence of hyperlipoproteinaemia(a) in SpA patients and analysed the possible related factors. Methods A baseline analysis was made of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients and controls included in the CARMA project (CARdiovascular in RheuMAtology), a 10-year prospective study evaluating the risk of CV events in chronic inflammatory rheumatic diseases. A multivariate logistic regression model was performed using hyperlipoproteinaemia( a) (Lp(a) >50 mg/dl) as a dependent variable and adjusting for confounding factors. Results 19.2% (95% CI: 16.80-22.05) of the SpA patients [20.7% (95% CI: 16.91-24.82) of those with AS and 17.7% (95% CI: 14.15-21.75) of those with PsA] and 16.7% (95% CI: 13.23-20.86) of the controls had hyperlipoproteinaemia(a) (p=0.326). Adjusting for age and sex, SpA patients were more likely to have hyperlipoproteinaemia(a) than controls (OR: 1.43, 95% CI: 1.00-2.04; p=0.05), especially those with AS (OR: 1.81, 95% CI: 1.18-2.77; p=0.007). In the adjusted model, apolipoprotein B in all patients, non-steroidal anti-inflammatory drugs in AS, and female sex in PsA, were associated with hyperlipoproteinaemia(a). No disease-specific factors associated with hyperlipoproteinaemia(a) were identified. Conclusion SpA patients show a moderately increased risk of hyperlipoproteinaemia(a) compared to controls, especially those with AS. Lp(a) determination may be of interest to improve the CV risk assessment in SpA patients.

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