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The sensitivity of lymphocytic choriomeningitis virus (LCMV) and Tacaribe virus to several chemical reagents was investigated. The viruses were sensitive to lipid solvents (ether, chloroform) and to detergents (sodium desoxycholate and Triton X-100); they were rapidly inactivated by formalin, beta-propiolactone, hydrogen peroxide and chloramine B. The results obtained contribute to a more complete characterization of the biological features of the arenavirus group and may be useful for scientific research and manufacturing of viral preparations.

In a chronic experiment (up to 6 years) on dogs (13) a protracted functional overstrain of the CNS was associated with an additional action changing the hormonal background (castration and mercasolyl injection). A steady hypercholesteremia, atherosclerotic changes in different intraorganic arteries, particularly in the myocardium, developed in dogs; dystrophic processes occurred in the parenchyma of various organs. An important role of functional overstrain of the CNS as one of the leading factors of the "risk" determining the development of disturbances of the regulation of lipid metabolism and formation of the atherosclerotic process in the vessels was demonstrated.