1. Protective molecular mechanisms of resveratrol in UVR-induced Skin carcinogenesis
- Author
-
Saba Wasim Aziz and Moammir H. Aziz
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Skin Neoplasms ,Carcinogenesis ,Ultraviolet Rays ,Immunology ,Gene Expression ,Apoptosis ,Dermatology ,Resveratrol ,medicine.disease_cause ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,Stilbenes ,Autophagy ,medicine ,Animals ,Anticarcinogenic Agents ,Humans ,Immunology and Allergy ,Radiology, Nuclear Medicine and imaging ,integumentary system ,business.industry ,Incidence (epidemiology) ,Cell Cycle ,Treatment options ,Cancer ,General Medicine ,medicine.disease ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,Toxicity ,Skin cancer ,business - Abstract
Skin cancer is a major health problem worldwide. It is the most common cancer in the United States and poses a significant healthcare burden. Excessive UVR exposure is the most common cause of skin cancer. Despite various precautionary measures to avoid direct UVR exposure, the incidence of skin cancer and mortality related to it remains high. Furthermore, the current treatment options are expensive and have side effects including toxicity to normal cells. Thus, a safe and effective approach is needed to prevent and treat skin cancer. Chemopreventive strategy using naturally occurring compounds, such as resveratrol, is a promising approach to reduce the incidence of UVR-induced skin cancer and delay its progression. This review highlights the current body of evidence related to chemopreventive role of resveratrol and its molecular mechanisms in UVR-induced skin carcinogenesis.
- Published
- 2017