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1. Disclosing the involvement of proteases in an eczema murine animal model: perspectives for protease inhibitor-based therapies

Author

Ilana Cruz-Silva, Viviane Abreu Nunes, Mariana Rydlewski, Andrezza Justino Gozzo, Priscila Praxedes-Garcia, Adriana Aparecida Ferraz Carbonel, Aparecida Sadae Tanaka, and Mariana da Silva Araújo

Subjects
Mice, Cathepsin G, Neutrophils, Eczema, ECZEMA ANIMAL, Animals, Protease Inhibitors, General Medicine, Biochemistry, Cathepsins, Peptide Hydrolases
Abstract

Eczema is a skin condition characterized by itchy and inflammatory patches. The accumulation of neutrophils and the imbalance between enzymes and their inhibitors appears to be related to this condition. We proposed a neutrophil elastase (NE)-based eczema model in mice in order to verify histopathological features as well as the expression and activity of proteases and inhibitors. Mice skins were topically administered with human NE (0-2 pmol/cm

Published
2022

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