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1. Platinum Compounds: a New Class of Potent Antitumour Agents

Author

Virginia H. Mansour, Loretta VanCamp, Barnett Rosenberg, and James E. Trosko

Subjects
Cis dichlorodiammineplatinum, Chemotherapy, Multidisciplinary, endocrine system diseases, Cell division, Chemistry, medicine.medical_treatment, Platinum compounds, Antineoplastic Agents, Pharmacology, medicine.disease, Mice, medicine, Animals, Neoplasm, Platinum binding, Sarcoma, Leukemia L1210, Sarcoma 180, Platinum
Abstract

CERTAIN platinum compounds completely but reversibly iiihibit cell division in Gram-negative rods1–4. These compounds have been tested for antitumour activity and we report some of the preliminary results. The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice.

Published
1969

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