1. Congenital Zika syndrome is associated with maternal protein malnutrition
- Author
-
Paula N. Gonzalez, Átila Duque Rossi, C. K. N. Amorim, Zoltán Molnár, J. C. C. G. Ferreira, Patricia P. Garcez, Flávio Alves Lara, Renato S. Aguiar, Jimena Barbeito-Andrés, F. F. Dutra, R. O. Ferreira, Janaina Mota de Vasconcelos, Marcia C. Castro, Leila Chimelli, Claudio Gustavo Barbeito, João L.S.G. Vianez, R. V. Barbosa, Paula Pezzuto, M. P. C. De Souza, Maria Bellio, Ricardo Tadeu Lopes, Amilcar Tanuri, Patricia Cuervo, Marcelo T. Bozza, Luiza M. Higa, T. M. P. Santos, and Acp Dias
- Subjects
Microcephaly ,Epidemiology ,Biología ,Physiology ,Zika virus ,Disease Outbreaks ,purl.org/becyt/ford/1 [https] ,0302 clinical medicine ,Pregnancy ,BRAIN DEVELOPMENT ,Research Articles ,2. Zero hunger ,0303 health sciences ,Multidisciplinary ,Zika Virus Infection ,Brain ,Gene Expression Regulation, Developmental ,SciAdv r-articles ,Defici?ncia de Prote?na ,Organ Size ,Syndrome ,Viral Load ,3. Good health ,Female ,Viral load ,Brazil ,Research Article ,medicine.medical_specialty ,Offspring ,Medicina ,Neurogenesis ,Biology ,03 medical and health sciences ,Microcefalia ,Virology ,medicine ,Diet, Protein-Restricted ,Animals ,IMMUNOHISTOCHEMISTRY ,purl.org/becyt/ford/1.6 [https] ,MORPHOMETRICS ,030304 developmental biology ,Gravidez / gen?tica ,Body Weight ,Malnutrition ,Outbreak ,medicine.disease ,biology.organism_classification ,Embryo, Mammalian ,Zika virus / patogenicidade ,Mice, Inbred C57BL ,Animals, Newborn ,030217 neurology & neurosurgery ,Neuroscience - Abstract
Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS., La lista completa de autores que integran el documento puede consultarse en el archivo., Facultad de Ciencias Veterinarias
- Published
- 2020