1. Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017
- Author
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Vlastimil Křivda, Jitka Hornickova, Alexander Nagy, Kamil Sedlák, Roman Masopust, Lenka Černíková, Eliška Vitásková, and Ádám Dán
- Subjects
0301 basic medicine ,Czech ,040301 veterinary sciences ,media_common.quotation_subject ,Highly pathogenic ,Zoology ,Hemagglutinin Glycoproteins, Influenza Virus ,Biology ,medicine.disease_cause ,Virus ,Disease Outbreaks ,Birds ,Evolution, Molecular ,0403 veterinary science ,03 medical and health sciences ,H5 hemagglutinin ,Virology ,medicine ,Animals ,Influenza A Virus, H5N8 Subtype ,Phylogeny ,Czech Republic ,media_common ,Virulence ,Genetic Variation ,Microevolution ,Outbreak ,04 agricultural and veterinary sciences ,General Medicine ,language.human_language ,Influenza A virus subtype H5N1 ,030104 developmental biology ,Influenza A virus ,Influenza in Birds ,language ,Diversity (politics) - Abstract
Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.
- Published
- 2018