1. The response of glandular gastric transcriptome to T-2 toxin in chicks
- Author
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Jie-Fan Dai, Lv-Hui Sun, Desheng Qi, You-Wei Wang, Jing-Jing Luo, Yu Zhang, Ni-Ya Zhang, Jin-Tao Wei, Mahmoud Mohamed Khalil, and Hua Sun
- Subjects
Male ,medicine.medical_specialty ,Necrosis ,Administration, Oral ,Inflammation ,Biology ,Toxicology ,medicine.disease_cause ,Desquamation ,Transcriptome ,Internal medicine ,medicine ,Animals ,Edema ,RNA, Messenger ,Wound Healing ,Toxin ,General Medicine ,T-2 Toxin ,Endocrinology ,Gastric Mucosa ,Apoptosis ,medicine.symptom ,Carcinogenesis ,Wound healing ,Chickens ,Food Science - Abstract
This study was conducted to determine the effect of T-2 toxin on the transcriptome of the glandular stomach in chicks using RNA-sequencing (RNA-Seq). Four groups of 1-day-old Cobb male broilers (n = 4 cages/group, 6 chicks/cage) were fed a corn-soybean-based diet (control) and control supplemented with T-2 toxin at 1.0, 3.0, and 6.0 mg/kg, respectively, for 2 weeks. The histological results showed that dietary supplementation of T-2 toxin at 3.0 and 6.0 mg/kg induced glandular gastric injury including serious inflammation, increased inflammatory cells, mucosal edema, and necrosis and desquamation of the epithelial cells in the glandular stomach of chicks. RNA-Seq analysis revealed that there were 671, 1393, and 1394 genes displayed ≥2 (P
- Published
- 2019
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