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To prepare iodine-131(Collagen-chitosan microspheres (CCMSs) were prepared with type-Ⅰ collagen and chitosan using emulsification-chemical cross-linking method. The size of the CCMSs were determined by electron microscope.CCMSs were synthesized with a smooth and spherical shape and an average diameter of (5.1±1.2) μm. A radiolabeling rate of 86.10% was achieved.Biodegradable CCMSs were successfully prepared and radiolabeled. The

To establish a mouse model bearing human prostate cancer xenograft with bone metastasis by the monitoring with X-Ray, Micro CT, and ¹⁸F-NaF PET/CT.Sixteen male Balb/c nude mice were allocated into control (6 mice) and experimental group (10 mice). In experimental group, the mice were subjected to percutaneous injection of 2×10At 21 d post modeling, the significant radioactive ¹⁸F--NaF signals were found in the tibial intramedullary cavity of all 10 mice in experimental group. The ROI value evaluation showed that SUVBone metastasis model of prostate PC-3 cancer cells were successfully established by intratibial injection. ¹⁸F-NaF PET/CT could detect tumor invasion and bone osteogenesis in the early stage of modeling.