1. Prolactin, growth hormone, and IGF-1 in ankles and plasma of adjuvant arthritic rats.
- Author
-
Elhassan, Adlan, Adem, Abdu, Suliman, Isam, Mustafa, Amged, Lindgren, J.U, Elhassan, A M, Adem, A, Suliman, I A, and Mustafa, A
- Subjects
- *
RHEUMATOID arthritis , *PROLACTIN , *SOMATOTROPIN , *ANIMAL models in research , *SOMATOMEDIN , *REFERENCE values , *CHRONIC diseases , *BLOOD plasma , *ANKLE , *HUMAN growth hormone , *RATS , *ARTHRITIS , *TISSUE extracts , *ANIMALS , *ACUTE diseases - Abstract
In this study we have investigated the levels of prolactin, growth hormone, and insulin-like growth factor-1 in plasma and in tissue extracts of ankle joints of rats with acute or chronic adjuvant arthritis using enzyme immunoassay (EIA) and radioimmunoassay (RIA). We found a stable content of prolactin in plasma of the different groups but a significantly increased concentration of growth hormone was observed in the plasma of the group with chronic arthritis. Moreover, an increased concentration of insulin-like growth factor-1 was noted in the plasma of the acute group. This evidently had returned to normal levels in the chronic group. In contrast, decreased concentrations of prolactin, growth hormone, and insulin-like growth factor-1 were found in tissue extracts of ankle joints of the group with chronic arthritis. The changes in the levels of these hormones in adjuvant arthritis might suggest that they play a role in the pathogenesis of the disease. Understanding the mechanism(s) of hormonal participation in adjuvant arthritis may open new treatment strategies for rheumatoid arthritis and other inflammatory disorders. [ABSTRACT FROM AUTHOR]
- Published
- 1999
- Full Text
- View/download PDF