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The infusions of the aerial parts in blossom of Hypericum canariense, H. glandulosum, H. reflexum and H. grandifolium (Hypericaceae) were evaluated for their pharmacological activity on the central nervous system in mice using various behavioural models including locomotor and muscle relaxant activity, effect on normal body temperature, pentobarbital-induced sleep, oxotremorine and tetrabenazine-induced syndrome, apomorphine-induced hypothermia and 5-hydroxytryptophan-induced head twitches, as well as a forced swimming test. These infusions did not alter significantly the locomotor activity, pentobarbital induced sleeping time and body temperature, with the exception of H. canariense which produced a slight but significant hypothermia. Additionally, no muscle relaxant or anticholinergic activity were observed. These infusions antagonized the ptosis and/or motor depression induced by tetrabenazine as well as shortening the immobility time in the forced swimming test. The observations suggest that the infusions of these Hypericum species possess antidepressant activity in mice, without inducing muscle relaxation, anticholinergic and sedative properties.

As an extension of a previous work, in which a number of 4H-pyrrolo-[1,2-a]thieno[2,3-f][1,4]diazepines were described, a new series of derivatives of the isomeric pyrrolo[1,2-a]thieno[3,2-f]diazepines ring system has been synthesized. The products obtained, together with those reported in the previous paper, were tested for acute toxicity and CNS activity in mice. 4H-Pyrrolo[1,2-a]thieno[3,2-f] und 4H-Pyrrolo[1,2-a]thieno[2,3-f]-[1,4]diazepine: Synthese und pharmakologische Untersuchung Als Erganzung zu unserer vorangehenden Arbeit, in der eine Reihe von 4H-Pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepinen beschrieben wurde, wurden Derivative des isomeren Pyrrolo[1,2-a]thieno[3,2]-f Ringsystems synthetisiert. Die erhaltenen Verbindungen - zusammen mit den in der vorangehenden Publikation beschriebenen Verbindungen - wurden auf ihre akute Toxizitat und CNS-Wirkung an Mausen untersucht.