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1. Delayed liver regeneration in C3H/HeJ mice: possible involvement of haemodynamic and structural changes in the hepatic microcirculation

Author

Muhamad, Marlini, Ayako, Mabuchi, Beth L, Mallard, Ngatiman, Hairulhisyam, Sachiko, Akashi-Takamura, Jacquie L, Harper, and Antony M, Wheatley

Subjects
Lipopolysaccharides, Mice, Inbred C57BL, Toll-Like Receptor 4, Mice, Inbred C3H, Liver, Microcirculation, Hemodynamics, Hepatocytes, Animals, Liver Regeneration
Abstract

What is the central question of this study? The liver regenerative process is complex and involves a sequence of signalling events, but the possible involvement of structural and haemodynamic changes in vivo during this process has never been explored. What is the main finding and its importance? Normal sinusoidal blood flow and velocity are crucial for a normal regenerative response, and delays in these haemodynamic events resulted in impaired liver regeneration in lipopolysaccharide-insensitive, C3H/HeJ mice. Toll-like receptor 4 signalling is required for restoration of normal liver architecture during the liver regenerative process. Liver regeneration is delayed in mice with a defective Toll-like receptor 4 (TLR4; C3H/HeJ mice) but is normal in TLR4 knockouts (TLR4

Published
2016

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