1. Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions
- Author
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Bernard C. Boswell, Brooke M. Helfer, Kristiina Vuori, Steven M. Frisch, Tae Bong Kang, Andrea Dorfleutner, Jill M. Lahti, Angel Cipres, David Wallach, Daniel C. Flynn, and Darren Finlay
- Subjects
Cancer Research ,Programmed cell death ,Motility ,Apoptosis ,Caspase 8 ,Cell Line ,Mice ,Cell Movement ,Animals ,chemistry.chemical_classification ,Mice, Knockout ,biology ,Calpain ,Biological activity ,Fibroblasts ,Embryo, Mammalian ,Cell biology ,Enzyme Activation ,Enzyme ,Oncology ,chemistry ,Tumor progression ,Caspases ,biology.protein ,Function (biology) - Abstract
Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we report that caspase-8 promotes cell motility. In particular, caspase-8 is required for the optimal activation of calpains, Rac, and lamellipodial assembly. This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling. (Cancer Res 2006; 66(8): 4273-8)
- Published
- 2006