1. Quantification of 16 cephalosporins in the aquatic environment by liquid chromatography-tandem mass spectrometry
- Author
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Mohamed M. Y. Kaddah, Emad H. Al‐Dokhmaisy, Basem Mansour, Hoda G. Daabees, and Miranda F. Kamal
- Subjects
Spectrometry, Mass, Electrospray Ionization ,Tandem Mass Spectrometry ,Solid Phase Extraction ,Animals ,Humans ,COVID-19 ,Filtration and Separation ,Chromatography, High Pressure Liquid ,Analytical Chemistry ,Chromatography, Liquid ,Cephalosporins - Abstract
Antimicrobial agents are essential to protect human and animal health. During the coronavirus disease 2019 pandemic, antimicrobials such as cephalosporins were widely used as prophylactics and to prevent bacterial co-infection. Undoubtedly, the prevalence of antibiotics in the aquatic environment will ultimately affect the degree of resistance against these bacteria in animals and the environmental systems. In order to monitor 16 cephalosporins in the aquatic environment, we developed a new liquid chromatography-tandem mass spectrometry method that functioned simultaneously under positive and negative electrospray ionization switching modes. The chromatographic separation has been implemented using a pentafluorophenyl propyl column kept at 40°C. The limits of detection and quantitation for the studied cephalosporins ranged from (8 × 10
- Published
- 2022