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1. Activities of Dicationic Compounds against Trichomonas vaginalis

Author

David W. Boykin, Arvind Kumar, Chad E. Stephens, Andrea L. Crowell, and W. Evan Secor

Subjects
Magnetic Resonance Spectroscopy, Antitrichomonal Agents, medicine.disease_cause, Microbiology, Trichomonadida, chemistry.chemical_compound, Drug Resistance, Fungal, Cations, Metronidazole, Trichomonas vaginalis, medicine, Animals, Parasite hosting, Pharmacology (medical), Anaerobiosis, Pharmacology, biology, DNA, Protozoan, Chemistry, Biosynthesis, biology.organism_classification, Aerobiosis, Antitrichomonal agent, Metabolic pathway, Infectious Diseases, chemistry, Biochemistry, Nitroimidazoles, Protozoa, medicine.drug
Abstract

We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.

Published
2004

2. In Vitro Metronidazole and Tinidazole Activities against Metronidazole- Resistant Strains of Trichomonas vaginalis

Author

W. Evan Secor, Andrea L. Crowell, and Kolby Sanders-Lewis

Subjects
Drug Resistance, Drug resistance, medicine.disease_cause, Tinidazole, Microbiology, Trichomonadida, Trichomonas Vaginitis, Metronidazole, Trichomonas vaginalis, medicine, Animals, Humans, Pharmacology (medical), Pharmacology, Trichomoniasis, biology, biology.organism_classification, medicine.disease, In vitro, Infectious Diseases, Susceptibility, Female, medicine.drug
Abstract

The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.

Published
2003

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