1. Activities of Dicationic Compounds against Trichomonas vaginalis
- Author
-
David W. Boykin, Arvind Kumar, Chad E. Stephens, Andrea L. Crowell, and W. Evan Secor
- Subjects
Magnetic Resonance Spectroscopy ,Antitrichomonal Agents ,medicine.disease_cause ,Microbiology ,Trichomonadida ,chemistry.chemical_compound ,Drug Resistance, Fungal ,Cations ,Metronidazole ,Trichomonas vaginalis ,medicine ,Animals ,Parasite hosting ,Pharmacology (medical) ,Anaerobiosis ,Pharmacology ,biology ,DNA, Protozoan ,Chemistry ,Biosynthesis ,biology.organism_classification ,Aerobiosis ,Antitrichomonal agent ,Metabolic pathway ,Infectious Diseases ,chemistry ,Biochemistry ,Nitroimidazoles ,Protozoa ,medicine.drug - Abstract
We evaluated 44 novel cationic compounds for activity against metronidazole-sensitive and -resistant Trichomonas vaginalis isolates. Six compounds in three different structural classes demonstrated 50% inhibitory concentrations as low as 1 μM against both sensitive and resistant isolates, suggesting a mode of action independent of parasite biochemical pathways that confer resistance to 5-nitroimidazoles.
- Published
- 2004