Search

Your search keyword '"Agraw Amane"' showing total 3 results
Start Over Author "Agraw Amane" Topic animals
3 results on '"Agraw Amane"'

1. Genome-wide insights of Ethiopian indigenous sheep populations reveal the population structure related to tail morphology and phylogeography

Author

Getinet Mekuriaw Tarekegn, Tesfaye Getachew, Adebabay Kebede, Yao Nasser, Agraw Amane, Tadelle Dessie, Zewdu Edea, Olivier Hanotte, Gurja Belay, Martina Kyalo, and Jean-Baka Domelevo Entfellner

Subjects
Tail, 0106 biological sciences, 0301 basic medicine, Animal breeding, Genotype, Zoology, Biology, Population structure, Disease cluster, Polymorphism, Single Nucleotide, 010603 evolutionary biology, 01 natural sciences, Biochemistry, Genome, Genetic diversity, Indigenous, Fat-tail, 03 medical and health sciences, Population Groups, Genetics, Animals, Humans, Ovine 50 K SNP, Molecular Biology, Sheep, Genetic Variation, Phylogeography, 030104 developmental biology, Genetic structure, Ethiopia, Genome-Wide Association Study, Research Article
Abstract

Background Ethiopian sheep living in different climatic zones and having contrasting morphologies are a most promising subject of molecular-genetic research. Elucidating their genetic diversity and genetic structure is critical for designing appropriate breeding and conservation strategies. Objective The study was aimed to investigate genome-wide genetic diversity and population structure of eight Ethiopian sheep populations. Methods A total of 115 blood samples were collected from four Ethiopian sheep populations that include Washera, Farta and Wollo (short fat-tailed) and Horro (long fat-tailed). DNA was extracted using Quick-DNA™ Miniprep plus kit. All DNA samples were genotyped using Ovine 50 K SNP BeadChip. To infer genetic relationships of Ethiopian sheep at national, continental and global levels, genotype data on four Ethiopian sheep (Adilo, Arsi-Bale, Menz and Black Head Somali) and sheep from east, north, and south Africa, Middle East and Asia were included in the study as reference. Results Mean genetic diversity of Ethiopian sheep populations ranged from 0.352 ± 0.14 for Horro to 0.379 ± 0.14 for Arsi-Bale sheep. Population structure and principal component analyses of the eight Ethiopian indigenous sheep revealed four distinct genetic cluster groups according to their tail phenotype and geographical distribution. The short fat-tailed sheep did not represent one genetic cluster group. Ethiopian fat-rump sheep share a common genetic background with the Kenyan fat-tailed sheep. Conclusion The results of the present study revealed the principal component and population structure follows a clear pattern of tail morphology and phylogeography. There is clear signature of admixture among the study Ethiopian sheep populations

Published
2020
Full Text
View/download PDF

2. Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

Author

Zhi-Qiang Shen, Juha Kantanen, Peng-Cheng Wan, Johannes A. Lenstra, Meng-Hua Li, Min Shen, James Kijas, Ping Zhou, Ji Yang, Juan Deng, EEr Hehua, Yong-Lin Yang, Olivier Hanotte, Jian-Lin Han, Yang Jingquan, Xinhua Wang, Zhang Yunsheng, Liu Changbin, Mostafa Dehghani-Qanatqestani, Ondřej Štěpánek, Ali Esmailizadeh, C. Weimann, Pi Wenhui, Feng-Hua Lv, David W. Coltman, Lei Gao, Xin Li, Michael William Bruford, Ya-Xi Xu, Guangjian Liu, Feng Wang, Yan-Ling Ren, Xing-Long Xie, Agraw Amane, Joram M. Mwacharo, Kathiravan Periasamy, Hua Yang, Song-Song Xu, Georg Erhardt, Hosein Salehian-Dehkordi, Sub Cellular Protein Chemistry, One Health Toxicologie, and Afd Pharmacology

Subjects
0301 basic medicine, Candidate gene, General Physics and Astronomy, Breeding, Linkage Disequilibrium, 0302 clinical medicine, Gene Frequency, Sequencing, Animal Husbandry, lcsh:Science, Ovis, Platelet-Derived Growth Factor, Multidisciplinary, biology, High-Throughput Nucleotide Sequencing, Genomics, Phenotype, Female, Agricultural genetics, Genotype, Science, Animals, Wild, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Species Specificity, Genetic variation, Genetics, Animals, Allele, Selection, Genetic, Domestication, Allele frequency, Gene, Alleles, Sheep, Domestic, Sheep, Whole Genome Sequencing, Genetic Variation, General Chemistry, Sequence Analysis, DNA, biology.organism_classification, 030104 developmental biology, Evolutionary biology, Mutation, lcsh:Q, 030217 neurology & neurosurgery
Abstract

Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals., Genetic resources for livestock are valuable for understanding their demography and past selection, and may inform future breeding programs and agricultural improvement. Here, the authors present deep resequencing of 248 wild and domestic sheep, with associated data and analysis.

Published
2019
Full Text
View/download PDF

3. Whole-genome resequencing of worldwide wild and domestic sheep elucidates genetic diversity, introgression, and agronomically important loci

Author

Lv, Feng-Hua, Cao, Yin-Hong, Liu, Guang-Jian, Luo, Ling-Yun, Lu, Ran, Liu, Ming-Jun, Li, Wen-Rong, Zhou, Ping, Wang, Xin-Hua, Shen, Min, Gao, Lei, Yang, Jing-Quan, Yang, Hua, Yang, Yong-Lin, Liu, Chang-Bin, Wan, Peng-Cheng, Zhang, Yun-Sheng, Pi, Wen-Hui, Ren, Yan-Ling, Shen, Zhi-Qiang, Wang, Feng, Wang, Yu-Tao, Li, Jin-Quan, Salehian-Dehkordi, Hosein, Hehua, Eer, Liu, Yong-Gang, Chen, Jian-Fei, Wang, Jian-Kui, Deng, Xue-Mei, Esmailizadeh, Ali, Dehghani-Qanatqestani, Mostafa, Charati, Hadi, Nosrati, Maryam, Štěpánek, Ondřej, Rushdi, Hossam E., Olsaker, Ingrid, Curik, Ino, Gorkhali, Neena A., Paiva, Samuel R., Caetano, Alexandre R., Ciani, Elena, Amills, Marcel, Weimann, Christina, Erhardt, Georg, Amane, Agraw, Mwacharo, Joram M., Han, Jian-Lin, Hanotte, Olivier, Periasamy, Kathiravan, Johansson, Anna M., Hallsson, Jón H., Kantanen, Juha, Coltman, David W., Bruford, Michael W., Lenstra, Johannes A., Li, Meng-Hua, Nowick, Katja, National Natural Science Foundation of China, National Key Research and Development Program (China), Chinese Academy of Sciences, FENG-HUA LV, China Agricultural University, China, YIN-HONG CAO, Chinese Academy of Sciences (CAS), China, GUANG-JIAN LIU, Novogene Bioinformatics Institute, China, LING-YUN LUO, China Agricultural University, China, RAN LU, China Agricultural University, China, MING-JUN LIU, Xinjiang Academy of Animal Science, China, WEN-RONG LI, Xinjiang Academy of Animal Science, China, PING ZHOU, Xinjiang Academy of Agricultural and Reclamation Sciences, China, XIN-HUA WANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, MIN SHEN, Xinjiang Academy of Agricultural and Reclamation Sciences, China, LEI GAO, Xinjiang Academy of Agricultural and Reclamation Sciences, China, JING-QUAN YANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, HUA YANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, YONG-LIN YANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, CHANG-BIN LIU, Xinjiang Academy of Agricultural and Reclamation Sciences, China, PENG-CHENG WAN, Xinjiang Academy of Agricultural and Reclamation Sciences, China, YUN-SHENG ZHANG, Xinjiang Academy of Agricultural and Reclamation Sciences, China, WEN-HUI PI, Xinjiang Academy of Agricultural and Reclamation Sciences, China, YAN-LING REN, Shandong Binzhou Academy of Animal Science and Veterinary Medicine, China, ZHI-QIANG SHEN, Shandong Binzhou Academy of Animal Science and Veterinary Medicine, China, FENG WANG, Nanjing Agricultural University, China, YU-TAO WANG, Kashi University, China, JIN-QUAN LI, Inner Mongolia Agricultural University, China, HOSEIN SALEHIAN-DEHKORDI, Chinese Academy of Sciences (CAS), China, EER HEHUA, Ningxia Academy of Agriculture and Forestry Sciences, China, YONG-GANG LIU, Yunnan Agricultural University, China, JIAN-FEI CHEN, China Agricultural University, China, JIAN-KUI WANG, China Agricultural University, China, XUE-MEI DENG, China Agricultural University, China, ALI ESMAILIZADEH, Shahid Bahonar University of Kerman, Iran, MOSTAFA DEHGHANI-QANATQESTANI, Shahid Bahonar University of Kerman, Iran, HADI CHARATI, Shahid Bahonar University of Kerman, Iran, MARYAM NOSRATI, Payame Noor University, Iran, ONDREJ STEPANEK, State Veterinary Institute Jihlava, Czech Republic, HOSSAM E. RUSHDI, Cairo University, Egypt, INGRID OLSAKER, Norwegian University of Life Sciences, Norway, INO CURIK, University of Zagreb, Croatia, NEENA A. GORKHALI, Nepal Agriculture Research Council (NARC), Nepal, SAMUEL REZENDE PAIVA, Cenargen, ALEXANDRE RODRIGUES CAETANO, Cenargen, ELENA CIANI, Universita degli Studi di Bari Aldo 24 Moro, Italy, MARCEL AMILLS, Campus de la Universitat Autonoma de Barcelona, Spain, CHRISTINA WEIMANN, Justus-Liebig-University Giessen, Germany, GEORG ERHARDT, Justus-Liebig-University Giessen, Germany, AGRAW AMANE, Addis Ababa University, Ethiopia, JORAM M. MWACHARO, International Centre for Agricultural Research in the Dry Areas (ICARDA), Ethiopia, JIAN-LIN HAN, Chinese Academy of Agricultural Sciences (CAAS), China, OLIVIER HANOTTE, International Livestock Research Institute, Ethiopia, KATHIRAVAN PERIASAMY, International Atomic Energy Agency (IAEA), Austria, ANNA M. JOHANSSON, Swedish University of Agricultural Sciences, Sweden, JON H. HALLSSON, Agricultural University of Iceland, Iceland, JUHA KANTANEN, Natural Resources Institute Finland (Luke), Finland, DAVID W. COLTMAN, University of Alberta, Edmonton, Canada, MICHAEL W. BRUFORD, Cardiff University, United Kingdom, JOHANNES A. LENSTRA, Utrecht University, The Netherlands, and MENG-HUA LI, China Agricultural University, China.

Subjects
Asia, Genome, Sheep, Whole-genome sequences, Genetic Variation, Genetic selection, Sequence Analysis, DNA, Iran, Polymorphism, Single Nucleotide, Genetic diversity, whole-genome sequences, genetic diversity, adaptive introgression, genetic selection, agronomic traits, migration, Europe, Adaptive introgression, Genetics, Animals, Agronomic traits, Molecular Biology, Sheep, Domestic, Ecology, Evolution, Behavior and Systematics, Migration
Abstract

Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but their genome landscapes remain understudied. Here, we present a comprehensive genome resource for wild ovine species, landraces and improved breeds of domestic sheep, comprising high-coverage (∼16.10×) whole genomes of 810 samples from 7 wild species and 158 diverse domestic populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 million of which are novel. Some display significant (P < 0.001) differences in frequency between wild and domestic species, or are private to continent-wide or individual sheep populations. Retained or introgressed wild gene variants in domestic populations have contributed to local adaptation, such as the variation in the HBB associated with plateau adaptation. We identified novel and previously reported targets of selection on morphological and agronomic traits such as stature, horn, tail configuration, and wool fineness. We explored the genetic basis of wool fineness and unveiled a novel mutation (chr25: T7,068,586C) in the 3′-UTR of IRF2BP2 as plausible causal variant for fleece fiber diameter. We reconstructed prehistorical migrations from the Near Eastern domestication center to South-and-Southeast Asia and found two main waves of migrations across the Eurasian Steppe and the Iranian Plateau in the Early and Late Bronze Ages. Our findings refine our understanding of genome variation as shaped by continental migrations, introgression, adaptation, and selection of sheep., This study was financially supported by grants from the National Natural Science Foundation of China (Nos. 32061133010, 31825024, 31661143014, and 31972527), the National Key Research and Development Program-Key Projects of International Innovation Cooperation between Governments (2017YFE0117900), the External Cooperation Program of Chinese Academy of Sciences (152111KYSB20150010), and the Second Tibetan Plateau Scientific Expedition and Research Program (STEP) (No. 2019QZKK0501), and the Special Funds of the State Key Laboratory of Sheep Genetic Improvement and Healthy Production (Nos. 2018CA001, and 2019CA009, 2020CA001).

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results