1. The first total synthesis of lactonamycin, a hexacyclic antitumor antibiotic
- Author
-
Seijiro Hosokawa, Hiroaki Tanaka, Hitomi Tsukagoshi, Takafumi Kashima, and Kuniaki Tatsuta
- Subjects
chemistry.chemical_classification ,animal structures ,Glycosylation ,Stereochemistry ,medicine.drug_class ,Organic Chemistry ,Antibiotics ,Total synthesis ,Alcohol ,Thioester ,Biochemistry ,chemistry.chemical_compound ,chemistry ,Intramolecular force ,Drug Discovery ,medicine ,lipids (amino acids, peptides, and proteins) ,Stereoselectivity ,Conjugate - Abstract
The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael–Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.
- Published
- 2010
- Full Text
- View/download PDF