1. Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish.
- Author
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de Abreu, Murilo S., Demin, Konstantin A., Kotova, Maria M., Mirzaei, Foad, Shariff, Sanobar, Kantawala, Burhan, Zakharchenko, Ksenia V., Kolesnikova, Tatiana O., Dilbaryan, Karen, Grigoryan, Artem, Yenkoyan, Konstantin B., and Kalueff, Allan V.
- Subjects
BRACHYDANIO ,EPILEPSY ,NERVOUS system regeneration ,NEUROLOGICAL disorders ,NEUROPLASTICITY ,ION channels - Abstract
The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed 'mTORopathies'. Typically arising from mutations within the mTOR signaling pathway, these disorders are characterized by cortical malformations and other neuromorphological abnormalities that usually co-occur with severe, often treatment-resistant, epilepsy. Here, we discuss recent advances and current challenges in developing experimental models of mTOR-dependent epilepsy and other related mTORopathies, including using zebrafish models for studying these disorders, as well as outline future directions of research in this field. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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