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Start Over Author "Mathysen, D." Topic animal genome mapping
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1. Assignment[sup 1] of the mouse Extl1 gene to the distal part of chromosome 4 by in situ hybridization and radiation hybrid mapping.

Author

Mathysen, D., Wuyts, W., Bossuyt, P. J., Wauters, J. G., and van Hul, W.

Subjects
*LABORATORY mice, *EXOSTOSIS, *BONE diseases, *ANIMAL genome mapping, *PROTEINS, *CHROMOSOMES
Abstract

Recently, a family of homologous genes was identified, comprising EXT1 on 8q23->q24 and EXT2 on 11p12->p11, both causing multiple exostoses, and three EXT-like genes mapped on 1p36.1, 1p12->p11 and 8p22->p12 respectively. Functional studies have revealed that the EXT genes and EXTL2 are involved in heparan sulfate biosynthesis, while EXTL3 is thought to encode a receptor for Reg-proteins. However, the function of EXTL1 still remains to be elucidated. Here, we describe the mapping of the mouse Extl1 gene to the distal part of mouse chromosome 4.

Published
2001
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