1. Variation in Vertebrate Cis-Regulatory Elements in Evolution and Disease.
- Author
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Douglas, Adam T. and Hill, Robert E.
- Subjects
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ANIMAL diversity , *GENETIC regulation , *BIOLOGICAL evolution , *GENE enhancers , *ANIMAL variation , *ANIMAL species , *ANIMAL diseases , *ANIMAL genetics - Abstract
Much of the genetic information that drives animal diversity lies within the vast non-coding regions of the genome. Multi-species sequence conservation in non-coding regions of the genome flags important regulatory elements and more recently, techniques that look for functional signatures predicted for regulatory sequences have added to the identification of thousands more. For some time, biologists have argued that changes in cis-regulatory sequences create the basic genetic framework for evolutionary change. Recent advances support this notion and show that there is extensive genomic variability in non-coding regulatory elements associated with trait variation, speciation and disease. [ABSTRACT FROM AUTHOR]
- Published
- 2014