1. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice
- Author
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Sulaiman, M.R., Perimal, E.K., Akhtar, M.N., Mohamad, A.S., Khalid, M.H., Tasrip, N.A., Mokhtar, F., Zakaria, Z.A., Lajis, N.H., and Israf, D.A.
- Subjects
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ANTI-inflammatory agents , *LABORATORY mice , *GRANULOMA , *EDEMA , *ZINGIBER , *INTRAPERITONEAL injections , *ALTERNATIVE medicine , *ANALYSIS of variance , *ANIMAL experimentation , *BIOPHYSICS , *DOSE-effect relationship in pharmacology , *DRUG toxicity , *MATHEMATICS , *RESEARCH methodology , *MEDICINAL plants , *MICE , *RESEARCH funding , *STATISTICS , *PLANT extracts , *DATA analysis , *PHARMACODYNAMICS - Abstract
The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. [Copyright &y& Elsevier]
- Published
- 2010
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