4 results on '"yellow cattle"'
Search Results
2. Study on the Regulatory Mechanism of the PDK1-Mediated TGF-β/Smad Signaling Pathway in Hypoxia-Induced Yak Lungs.
- Author
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Zhang, Yiyang, Wang, Jun, Zhang, Meng, Li, Xiaoyun, Zhang, Fan, Zhou, Manlin, Yang, Kun, Chen, Weiji, Ding, Haie, Tan, Xiao, Zhang, Qian, and Qiao, Zilin
- Subjects
- *
PYRUVATE dehydrogenase kinase , *VASCULAR smooth muscle , *PULMONARY arterial hypertension , *YAK , *ANIMAL diseases - Abstract
Simple Summary: The lungs are key organs in mammals that shows adaptive changes in response to high altitude, and yaks (Bos grunniens) have adapted their lungs well to the hypoxic environment of Tibetan Plateau after a long period of evolution and natural selection. However, the long-term life of lowland cattle on the plateau can cause symptoms such as pulmonary arterial hypertension, wherein the abnormal proliferation of pulmonary vascular smooth muscle cells leads to the remodeling of the pulmonary vasculature, which is the main cause of pulmonary arterial hypertension. The underlying molecular mechanisms of lung adaptation to hypoxia in yaks remain largely unknown. In this study, we constructed stably transfected yak cell lines overexpressing PDK1 via lentiviral transfection, and we cultured yellow cattle and yak PASMCs, as well as PDK1-OEcon/OE, under normoxia and 10% O2 to explore the effects of hypoxia on the PDK1 and TGF-β/Smad signaling pathways in yak PASMCs. This will provide theoretical data at the cellular and molecular levels, along with basic information to further elucidate the mechanism of the PDK1-mediated TGF-β/Smad signaling pathway in yak PASMCs induced by hypoxia. The aim of this study was to investigate the effects of hypoxia-induced phenotype, glucose metabolism, ROS levels, and the PDK1-mediated regulation of TGF-β/Smad signaling in yellow cattles, yaks, and those overexpressing PDK1 PASMCs using growth curves, flow cytometry, scratch experiments, glucose and lactic acid assays, RT-qPCR, and Western blotting. The results showed that hypoxia significantly promoted proliferation, migration, antiapoptosis, ROS levels, glucose consumption, and lactate production in yellow cattle PASMCs (p < 0.05), and the cells were dedifferentiated from the contractile phenotype; conversely, hypoxia had no significant effect on yak PASMCs (p > 0.05). PDK1 overexpression significantly promoted proliferation, antiapoptosis, glucose consumption, and lactate production in yak PASMCs under normoxia and hypoxia (p < 0.05), decreased their migration levels under hypoxia (p < 0.05), and dedifferentiated the contractile phenotype of the cells. Overexpression of PDK1 in yak PASMCs is detrimental to their adaptation to hypoxic environments. Yak PASMCs adapted to the effects of hypoxia on lung tissue by downregulating the expression of genes related to the PDK1 and TGF-β/Smad signaling pathways. Taken together, the regulation of PDK1-mediated TGF-β/Smad signaling may be involved in the process of yaks' adaptation to the hypoxic environment of the plateau, reflecting the good adaptive ability of yaks. The present study provides basic information to further elucidate the mechanism of PDK1-mediated TGF-β/Smad signaling induced by hypoxia in the lungs of yaks, as well as target genes for the treatment of plateau diseases in humans and animals. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Influenza D Virus in Animal Species in Guangdong Province, Southern China
- Author
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He Zhang, Xiao-Hui Wen, Shao-Lun Zhai, Dian-Hong Lv, Wen-Kang Wei, Sheng-Nan Chen, Runxia Liu, Xia Zhou, Feng Li, Tao Lin, and Dan Wang
- Subjects
0301 basic medicine ,Microbiology (medical) ,China ,Lineage (genetic) ,Epidemiology ,viruses ,030106 microbiology ,lcsh:Medicine ,yellow cattle ,H5N1 genetic structure ,Virus ,Animal Diseases ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,American Landrace pigs ,Orthomyxoviridae Infections ,Animals ,Humans ,Viral rna ,lcsh:RC109-216 ,Geography, Medical ,influenza D virus ,Animal species ,D/OK lineage ,Phylogeny ,Feces ,biology ,lcsh:R ,Dispatch ,virus diseases ,hybrid goats ,biology.organism_classification ,Virology ,zoonoses ,030104 developmental biology ,Infectious Diseases ,hemagglutinin-esterase-fusion gene ,Influenza D Virus in Animal Species in Guangdong Province, Southern China ,Southern china ,Asian buffalo ,Thogotovirus ,influenza ,Holstein dairy cattle - Abstract
Molecular tests revealed influenza D viruses of D/OK lineage widely circulating in farmed animal species in Guangdong Province, southern China. In particular, we found high levels of influenza D virus infection in goats and pigs. We also detected viral RNA in serum specimens and feces of animals with certain severe diseases.
- Published
- 2017
4. The Impact of Crossbred Cattle (Red Sindhi×Yellow Local) on Smallholder Households in the Mountainous and Lowland Zones of Quang Ngai, Vietnam
- Author
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L. D. Phung and W. J. Koops
- Subjects
Yellow Cattle ,Animal Nutrition ,animal diseases ,Efficiency ,Crossbreed ,Animal Production Systems ,Crossbred ,Crop ,Agricultural science ,parasitic diseases ,Productivity ,Dierlijke Productiesystemen ,Agroforestry ,business.industry ,food and beverages ,Crossbred cattle ,Diervoeding ,Breed ,Households ,Geography ,Vietnam ,WIAS ,Animal Science and Zoology ,Livestock ,Mixed farming ,business ,Red Sindhi ,Food Science - Abstract
This research investigates the use of crossbreed cattle (Red SindhixYellow Local cattle) at household level in the lowland and mountainous zones in Quang Ngai province, Vietnam. The internal and external inputs and outputs of mixed farming systems were analysed to quantify the productivity and efficiency of the use of the crossbred and yellow local cattle. In the mountainous zone, households with crossbred cattle had a lower crop and farm efficiency rate than households without crossbred cattle, but in terms of crop, livestock and farm productivity they did not differ. In the lowland zone, households with crossbred cattle had a higher crop, livestock and farm productivity and crop efficiency rate than households without crossbred cattle, but did not differ in terms of farm efficiency rate. The lowland zone had higher off-farm income, crop and household productivity, but lower livestock productivity, livestock and farm efficiency rate than the mountainous zone. Households with crossbred cattle had lower off-farm income than households without crossbred cattle. The results suggest that interactions between zone and kind of household occur at the households and show that the yellow local cattle is a better breed in the mountainous zone and more or less comparable with crossbred cattle in the lowland zone. The extrapolation of the use of crossbred cattle should be carefully considered in line with feeding practice and management.
- Published
- 2003
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