1. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function.
- Author
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Pinnamaneni, Kranthi, Sievers, Richard E, Sharma, Rikki, Selchau, Amanda M, Gutierrez, Gustavo, Nordsieck, Eric J, Su, Robert, An, Songtao, Chen, Qiumei, Wang, Xiaoyin, Derakhshandeh, Ronak, Aschbacher, Kirstin, Heiss, Christian, Glantz, Stanton A, Schick, Suzaynn F, and Springer, Matthew L
- Subjects
Epidemiology ,Public Health ,Health Sciences ,Tobacco Smoke and Health ,Lung ,Tobacco ,Cancer ,Health Effects of Indoor Air Pollution ,Cardiovascular ,Animals ,Dilatation ,Pathologic ,Disease Models ,Animal ,Dose-Response Relationship ,Drug ,Endothelium ,Vascular ,Female ,Femoral Artery ,Humans ,Rats ,Rats ,Sprague-Dawley ,Time Factors ,Tobacco Smoke Pollution ,Clinical Sciences ,Public Health and Health Services ,Marketing ,Public health - Abstract
IntroductionWe sought to determine the effects of brief exposures to low concentrations of tobacco secondhand smoke (SHS) on arterial flow-mediated dilation (FMD, a nitric oxide-dependent measure of vascular endothelial function), in a controlled animal model never before exposed to smoke. In humans, SHS exposure for 30 min impairs FMD. It is important to gain a better understanding of the acute effects of exposure to SHS at low concentrations and for brief periods of time.MethodsWe measured changes in FMD in rats exposed to a range of real-world levels of SHS for durations of 30 min, 10 min, 1 min, and 4 breaths (roughly 15 s).ResultsWe observed a dose-response relationship between SHS particle concentration over 30 min and post-exposure impairment of FMD, which was linear through the range typically encountered in smoky restaurants and then saturated at higher concentrations. One min of exposure to SHS at moderate concentrations was sufficient to impair FMD.ConclusionsBrief SHS exposure at real-world levels reversibly impairs FMD. Even 1 min of SHS exposure can cause reduction of endothelial function.
- Published
- 2014