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Objective: To determine diagnostic accuracy of fractional flow reserve in diagnosing stentable intermediate stenosis in patients of coronary artery disease keeping angiography as gold standard. Study Design: Cross sectional validation study. Place and Duration of Study: Cardiology ward and Coronary Care Unit of PIMS Islamabad, from Jun 2015 to Nov 2015. Methodology: This study included 130 patients with coronary artery disease. General physical examination and systemic examination was done for all subjects as per protocol of inclusion and exclusion criteria. All the patients underwent Conventional angiography followed by fractional flow reserve in intermediate coronary artery disease. Diagnostic accuracy of fractional flow reserve was detected by determining sensitivity, specificity and accuracy. Results: The mean age of the patients was 56 ± 8.790 years, ranging from 31 to 72 years. There were 88 (67.7%) male patients and 42 (32.3%) female patients in the study. There were 31 true positive, 3 false negative and 92 were found true negative. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of fractional flow reserve for diagnosis of stentable intermediate stenosis was 91.2%, 95.8%, 88.6%, 96.8% and 94.6%, respectively. Conclusions: Fractional flow reserve is a reliable test for detection of stentable intermediate stenosis among patients with coronary artery disease and should be done in every case of coronary artery disease. [ABSTRACT FROM AUTHOR]