1. Granin-derived peptides.
- Author
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Troger, Josef, Theurl, Markus, Kirchmair, Rudolf, Pasqua, Teresa, Tota, Bruno, Angelone, Tommaso, Cerra, Maria C., Nowosielski, Yvonne, Mätzler, Raphaela, Troger, Jasmin, Gayen, Jaur R., Trudeau, Vance, Corti, Angelo, and Helle, Karen B.
- Subjects
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C-terminal residues , *AMINO acids , *PEPTIDES , *PROTEINS , *ANTHOPLEURIN - Abstract
The granin family comprises altogether 7 different proteins originating from the diffuse neuroendocrine system and elements of the central and peripheral nervous systems. The family is dominated by three uniquely acidic members, namely chromogranin A (CgA), chromogranin B (CgB) and secretogranin II (SgII). Since the late 1980s it has become evident that these proteins are proteolytically processed, intragranularly and/or extracellularly into a range of biologically active peptides; a number of them with regulatory properties of physiological and/or pathophysiological significance. The aim of this comprehensive overview is to provide an up-to-date insight into the distribution and properties of the well established granin-derived peptides and their putative roles in homeostatic regulations. Hence, focus is directed to peptides derived from the three main granins, e.g. to the chromogranin A derived vasostatins, betagranins, pancreastatin and catestatins, the chromogranin B-derived secretolytin and the secretogranin II-derived secretoneurin (SN). In addition, the distribution and properties of the chromogranin A-derived peptides prochromacin, chromofungin, WE14, parastatin, GE-25 and serpinins, the CgB-peptide PE-11 and the SgII-peptides EM66 and manserin will also be commented on. Finally, the opposing effects of the CgA-derived vasostatin-I and catestatin and the SgII-derived peptide SN on the integrity of the vasculature, myocardial contractility, angiogenesis in wound healing, inflammatory conditions and tumors will be discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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