1. The Roles of circRNAs in Liver Cancer Immunity
- Author
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Ying Tang, Mei Jiang, Hai-Mei Jiang, Zeng Jie Ye, Yu-Sheng Huang, Xiu-Shen Li, Bin-Yu Qin, Rui-Sheng Zhou, Hua-Feng Pan, and Da-Yong Zheng
- Subjects
Cancer Research ,Innate immune system ,Angiogenesis ,medicine.medical_treatment ,Review ,Immunotherapy ,natural killer (NK) cells ,Cell cycle ,Biology ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,lcsh:RC254-282 ,Metastasis ,liver cancer ,The Hallmarks of Cancer ,Immune system ,Oncology ,medicine ,Cancer research ,circRNA ,Liver cancer ,innate immunity ,immune evasion - Abstract
Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.
- Published
- 2021
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