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Your search keyword '"Liu, Jian-Miao"' showing total 3 results
Start Over Author "Liu, Jian-Miao" Topic angiogenesis
3 results on '"Liu, Jian-Miao"'

2. Evidence for an association of high levels of endogenous Acetyl-Ser-Asp-Lys-Pro, a potent mediator of angiogenesis, with acute myeloid leukemia development.

Author

Liu, Jian-Miao, Bignon, Jérôme, Ilic, Vesna, Briscoe, Cecilia, Lallemand, Jean-Yves, Riches, Andrew, and Wdzieczak-Bakala, Joanna

Subjects
*LEUKEMIA, *NEOVASCULARIZATION, *BLOOD-vessel development, *NONINVASIVE diagnostic tests, *PEPTIDE antibiotics, *BONE marrow
Abstract

Evidence from clinical and laboratory studies suggests that angiogenesis is important in the progression of solid tumours and hematologic malignancies. We have shown that the naturally occurring tetrapeptide Acetyl-Ser-Asp-Lys-Pro (AcSDKP) is a potent angiogenic factor normally present at nanomolar concentrations in the blood. A murine leukemia model was used to assess whether there was a correlation between levels of endogenous AcSDKP and the development of disease. Levels of AcSDKP in the plasma and bone marrow (BM) cells from mice bearing an acute myeloid leukemia (AML) were five- to ten-fold greater than those in non-leukemic mice. Furthermore, a strong correlation between the concentration of endogenous AcSDKP and the progression of AML was demonstrated. These results are consistent with the marked increase in BM vascularity observed in leukemic mice. The physiologic relevance of these findings awaits further studies and the contribution of AcSDKP to the pathogenesis of leukemia is under investigation. [ABSTRACT FROM AUTHOR]

Published
2006
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3. Overexpression of the angiogenic tetrapeptide AcSDKP in human malignant tumors

Author

Liu, Jian-Miao, Kusinski, Michal, Ilic, Vesna, Bignon, Jerome, Hajem, Neila, Komorowski, Jan, Kuzdak, Krzysztof, Henryk Stepien, Wdzieczak-Bakala, Joanna, Institut de Chimie des Substances Naturelles (ICSN), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
marker, angiogenesis, genetic structures, thyroid tumor, [CHIM.ORGA]Chemical Sciences/Organic chemistry, cancer, POP, AcSDKP, ComputingMilieux_MISCELLANEOUS
Abstract

Background: The natural tetrapeptide acetyl-SerAsp-Lys-Pro (AcSDKP), generated from thymosin beta 4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the critical role of neovascularisation in tumor development, the expression of AcSDKP and the activity of POP were examined in different human solid malignancies. Materials and Methods: The expression of AcSDKP and the activity of POP were evaluated in human blood samples and tissue specimens of thyroid goiter and thyroid papillary carcinoma as well as in commercial cancer tissue microarray. Results: A significantly increased concentration of AcSDKP in intratumoral blood and enhanced tissular activity of POP were detected in cancer patients. The expression of AcSDKP in human breast, colon, head and neck, kidney, lung, skin, ovary and prostate cancer tissues was shown to be greater than that in normal tissues. Conclusion: AcSDKP and POP contribute to the malignant phenotype and these molecules are potentiel markers of cancer.

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