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Objective: To analyze the correlation between human cytomegalovirus (HCMV) infection and the inflammatory mediators of patients with acute coronary syndrome (ACS), and explore the r ole of HCMV infection in the occurrence and development of ACS. Methods: 118 cases of coronary heart disease patients who were admitted to our hospital from May 2017 to May 2019 were selected, and they were divided into A CS group (n=81) and stable angina pectoris (SAP) group (n= 37) according to illness condition, another 40 healthy volunteers in our hospital who were selected as control group during the same period. The serum specific HC MV-IgG and HCMV-IgM were detected in all subjects, and the levels of serum sP-selection, tumor necrosis factor-a (TNF-a) and high sensitivity e-re-active protein (hs-CRP) were compared in all subjects. The correlation between serum sP-selectin, TNF-α and hs-CRP levels and the titer of HCMV-IgM antibody in patients of ACS group were analyzed. Results: The positive rates of HCMV-IgG in the ACS group and in the SAP group were 81.48% and 78.38% respectively, which were significantly higher than 45. 00% in the control group, and the differences were statistically significant (P<0.05). The positive rate of HCMV-IgM in the AC S group was 40.74%, which was significantly higher than 10.81% in the SAP group and 5.00% in the control group, and the differences were statistically significant (P<0.05). The levels of serum sP-selection, TNF-α and hs-CRP in the A CS group w er e significantly higher than those in the SAP group and in the control group, and the differ ences were statistically significant (P<0.05). The levels of serum serum sP-selection, TNF-α and hs-CRP in patients with HCMV- IgM positive in the ACS group were significantly higher than those in patients with HCMV-IgM negative, and the differences were statistically significant (?<0.05). The levels of serum sP-selection, TNF-α, hs-CRP in the ACS group were positively correlated with the titer of HCMV -IgM antibody (P