1. Clinical Application of Preimplantation Genetic Screening.
- Author
-
ZHANG Qian, ZHENG Ye, and YAN Jun-hao
- Subjects
HUMAN reproductive technology ,GENETIC testing ,HUMAN chromosome abnormality diagnosis ,HUMAN in vitro fertilization ,HUMAN embryo transfer - Abstract
With the development of assisted reproductive technology and genetic analysis technology, the preimplantation genetic screening (PGS) is used to detect the numerical chromosomal abnormalities (aneuploid) in embryos, so as to improve pregnancy outcomes of in vitro fertilization -embryo transfer (IVF -ET). New methods and technologies have been used in PGS, such as blastocyst stage biopsy, comparative genomic hybridization, microarrays and next generation sequencing, which increase the diagnose accuracy and decrease the risk of misdiagnosis. At the same time, PGS is also facing many challenges. The clinical application of PGS was reviewed in this article. [ABSTRACT FROM AUTHOR]
- Published
- 2014