1. Invitation to participate in a multi-center study for validation of cerebral computed tomography angiography and computed tomography perfusion in the determination of cerebral circulatory arrest during brain death/death by neurological criteria diagnosis procedure in paediatric population below 12 years of age
- Author
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Piotr Luchowski, Katarzyna Sznajder, Romuald Bohatyrewicz, Wojciech Walas, Maria Dziejowska, Andrzej Falba, Andrzej Piotrowski, Jacek Janica, Radosław Owczuk, Marcin Sawicki, Joanna Wojczal, Marek Migdał, Elżbieta Jurkiewicz, Wojciech Dąbrowski, Łukasz Wyrobek, Tamara Kołakowska, Krzysztof Kusza, Andrzej Kościesza, Zbigniew Serafin, Piotr Jakubów, Katarzyna Sierakowska, Beata Rybojad, Wojciech Poncyljusz, Katarzyna Chamier-Ciemińska, Joanna Sołek-Pastuszka, Magdalena Maria Woźniak, Mariola Tałałaj, Elżbieta Byrska-Maciejasz, Maciej Guziński, Marzena Zielińska, Krzysztof Kobylarz, Izabela Pągowska-Klimek, Elżbieta Milewicz-Podgórska, Katarzyna Jończyk-Potoczna, Monika Bekiesińska-Figatowska, Michał Brzewski, Alicja Bartkowska-Śniatkowska, Paweł Jurszewicz, and Edyta Szurowska
- Subjects
Brain Death ,medicine.medical_specialty ,Computed tomography perfusion ,Computed Tomography Angiography ,Cerebral arteries ,Critical Care and Intensive Care Medicine ,Anesthesiology ,icu ,medicine ,Humans ,RD78.3-87.3 ,Child ,Computed tomography angiography ,medicine.diagnostic_test ,RC86-88.9 ,business.industry ,Medical emergencies. Critical care. Intensive care. First aid ,General Medicine ,Time optimal ,Ultrasonography doppler ,Heart Arrest ,Perfusion ,lung microbiom ,Anesthesiology and Pain Medicine ,Multi center study ,Circulatory system ,lung-gut interaction ,Radiology ,Tomography, X-Ray Computed ,business ,Paediatric population - Abstract
In recent years commensal microorganisms are not just “passive occupants”, but important element of homeostasis. There are numerous reports documenting the composition and role of the gut, skin or vagina microbiome but the role of commensal organisms living in the lungs is relatively unknown. Pulmonary microbiome impact on the immune response of the host organism and may indicate new therapeutic directions. Lung microbiome, by modulating the expression of innate immunity genes, causes an increase in the concentration of IL-5, IL-10, IFNγ and CCL11, affects the TLR4 dependent response of pulmonary macrophages and modulate the production of antibacterial peptides contained in the mucus. It is documented that disorders of the lung microbiome contribute to asthma or chronic obstructive pulmonary disease. However it is known that pulmonary dysbiosis also occurs in critically ill patients. It is possible, therefore, that microbiota-targeted therapy may constitute the future therapeutic direction in ICU.
- Published
- 2021