1. Hemophagocytic Lymphohistiocytosis Associated With Hemolytic Uremic Syndrome in a Child: A Case Report and Systematic Literature Review
- Author
-
Rukiye Ünsal Saç, Burcu C.C. Yayla, Arife U. Gokceoglu, Ayşegul Ozcan, Bulent Alioglu, Nesrin Tas, and Emine Vezir
- Subjects
Male ,Hemophagocytic lymphohistiocytosis ,Pediatrics ,medicine.medical_specialty ,Anemia, Hemolytic ,business.industry ,Hematology ,Acute Kidney Injury ,medicine.disease ,Thrombocytopenia ,Lymphohistiocytosis, Hemophagocytic ,Systematic review ,Oncology ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Hemolytic-Uremic Syndrome ,medicine ,Humans ,business ,Child - Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder resulting from excessive activation and nonmalignant proliferation of T-lymphocytes and macrophages. Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Reports pertaining to the association between HLH and HUS are rarely published; however, we report on a 4-year-old boy who was diagnosed with both conditions and treated successfully with high-dose steroid and intravenous immunoglobulin. Differentiating HUS from HLH can be challenging because of their clinical similarities. Therefore, prompt diagnosis and immunosuppressive treatment are essential and life-saving to these patients.
- Published
- 2021