1. Predictors of severe anaphylaxis in Hymenoptera venom allergy
- Author
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Mathias Langner, Stefan Beissert, Maria Chapsa, Henriette Roensch, and Andrea Bauer
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Angioedema ,business.industry ,Immunology ,Hymenoptera venom allergy ,Retrospective cohort study ,medicine.disease ,Dermatology ,03 medical and health sciences ,Sting ,0302 clinical medicine ,030228 respiratory system ,medicine ,Immunology and Allergy ,030212 general & internal medicine ,Young adult ,Systemic mastocytosis ,medicine.symptom ,business ,Anaphylaxis ,Cohort study - Abstract
Background Severe anaphylaxis (SA) in Hymenoptera venom allergy has been associated with a number of risk factors. However, the effect of several of those risk factors on the severity of anaphylaxis is poorly defined. Objective To evaluate risk factors for SA in Hymenoptera venom allergy. Methods We evaluated data from 500 patients who were referred to our department for the diagnosis of Hymenoptera venom allergy during a period of 11 years to identify risk factors for SA. Results Six significant risk factors for SA were identified (P Conclusion Apart from BST and older age, male sex, short interval from sting to reaction, and absence of U/A are also risk factors for SA. The association between elevated BST level and SA was largely confined to those who had an absence of U/A after field sting, possibly because of the higher risk of concurrent systemic mastocytosis. Patients with an SA after a field sting do not have an elevated risk of systemic reactions during the initiation of venom immunotherapy compared with patients with mild anaphylaxis; therefore, additional preventive measures are not necessary.
- Published
- 2020