1. Acrolein: blocking antibody formation: pro tumor, anti-allergy
- Author
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Franziska Roth-Walter, Anna Willensdorfer, Caroline Stremnitzer, Cornelia Schultz, Susanne Diesner, Krisztina Szalai, Judit Fazekas, Anna Moskovskich, Alina Neunkirchner, Hanna Birnleitner, and Erika Jensen-Jarolim
- Subjects
Pulmonary and Respiratory Medicine ,Allergy ,business.industry ,Cytokine profile ,Immunology ,Acrolein ,Anaphylactic reaction ,hemic and immune systems ,chemical and pharmacologic phenomena ,medicine.disease ,complex mixtures ,Molecular biology ,biological factors ,chemistry.chemical_compound ,chemistry ,In vivo ,Poster Presentation ,Blocking antibody ,Splenocyte ,Immunology and Allergy ,Medicine ,Tumor growth ,business ,therapeutics - Abstract
Methods BALB/c mice were nasally sensitized 5 times in biweekly intervals with KLH alone or with KLH in conjunction with acrolein. Airway hyperreactivity was was measured according to change of enhanced pause and KLH-specific anaphylactic reaction was monitored in vivo Levels of specific antibodies as well as cytokine profile of KLH-stimulated splenocytes were analyzed by ELISA. Further, mouse D2F2-tumor cells were grafted to the flanks and tumor growth monitored in mice previously exposed to acrolein or buffer.
- Published
- 2014
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