1. Bioactive oligostilbenoids from Shorea maxwelliana King and their chemotaxonomic significance
- Author
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N.H. Wahid, A.S. Sufian, N.K.N.A. Zawawi, R.M. Shafiq, Norizan Ahmat, and M.Z. Mazatulikhma
- Subjects
Stem bark ,Dipterocarpaceae ,Traditional medicine ,Cell Survival ,Plant Extracts ,Organic Chemistry ,HL-60 Cells ,Plant Science ,Biology ,Shorea maxwelliana ,biology.organism_classification ,Biochemistry ,Analytical Chemistry ,Phytochemical ,Chemotaxonomy ,Stilbenes ,Botany ,Plant Bark ,Ic50 values ,Cultured cell ,Humans ,Viability assay ,Benzofurans - Abstract
Phytochemical investigation on the stem bark of Shorea maxwelliana yielded five oligostilbenoids identified as α-viniferin (1), maximol A (2), vaticanol A (3), suffruticosol A (4) and vaticanol G (5). Chemotaxonomy of isolated compounds was discussed briefly. Major compounds were tested for neurotoxic and cytotoxic activities. Neurotoxicity for all tested compounds did not pose any toxic effect against cultured cell (cell viability range ±100-94%). Compounds 2-5 possessed active cyctotoxic activity against HL60 cell line with IC50 values range of 2.7-78 µg mL(-1).
- Published
- 2012
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