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Objective: To evaluate the influence of surface treatment on roughness (SA), topography, and shear bond strength (SBS) of computer‐aided designer and manufacture (CAD/CAM) zirconia‐reinforced lithium silicate (ZLS) and feldspathic (FEL) glass–ceramics. Materials and methods: FEL and ZLS specimens were submitted to 5% or 10% hydrofluoric acid (HF) or self‐etching ceramic primer (MEP) and different application times (20, 40, and 60 s), or to sandblasting (Control, 20 s). Resin cement cylinders were bonded to the specimens and tested in shear (n = 10) after 24 h and 16‐months of water storage. SA and topography were evaluated by atomic force (AFM, n = 10) and scanning electron microscopy. Data were analyzed by ANOVA and Bonferroni test (α = 0.05). Results: Sandblasting promoted the highest SA for ZLS, but 10% HF (40, 60 s) promoted higher SBS at 16 months. 10% HF produced the highest SA for FEL, but sandblasting and 5% HF (20 s) maintained SBS after 16 months, without differences from 10% HF (20 s) (p > 0.05). Overall, MEP produced lower SA and SBS among groups (p < 0.05). HF displayed greater morphological changes on FEL. Conclusion: 10% HF (40 s) provided better results for ZLS, while 5% or 10% HF (20 s) was suitable for FEL. Clinical significance: Surface treatments influenced SA, topography, and SBS of materials. HF etching is the surface treatment of choice for both CAD/CAM glass–ceramics. [ABSTRACT FROM AUTHOR]