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In this article, finite element simulations and response surface method are used to optimize perforated plate parameters for ballistic protection. After statistically validating the relationship between residual velocity and geometric parameters, a response optimizer was used to find the best combination of design parameters to stop a threat with less areal density. Finally, the optimized solution was checked both numerically and experimentally to show the effectiveness of the developed methodology. The weight is decreased by 28% when compared with monolithic steel armor having the same antiballistic performance. [ABSTRACT FROM PUBLISHER]