1. Impact of hypoalbuminemia on outcomes following pancreaticoduodenectomy: a NSQIP retrospective cohort analysis of 25,848 patients.
- Author
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Sawchuk, Taylor, Verhoeff, Kevin, Jogiat, Uzair, Mocanu, Valentin, Shapiro, A. M. James, Anderson, Blaire, Dajani, Khaled, and Bigam, David L.
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RISK assessment , *PREOPERATIVE period , *GOODNESS-of-fit tests , *BODY mass index , *RECEIVER operating characteristic curves , *MULTIPLE regression analysis , *SEX distribution , *SMOKING , *QUESTIONNAIRES , *BLOOD protein disorders , *TREATMENT effectiveness , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *DISEASE prevalence , *AGE distribution , *PANCREATICODUODENECTOMY , *SURGICAL complications , *LONGITUDINAL method , *ODDS ratio , *MEDICAL records , *ACQUISITION of data , *ANALYSIS of variance , *STATISTICS , *ALBUMINS , *CONFIDENCE intervals , *COMORBIDITY , *DISEASE risk factors ,MORTALITY risk factors - Abstract
Background: Efforts to preoperatively risk stratify and optimize patients before pancreaticoduodenectomy continue to improve outcomes. This study aims to determine the impact of hypoalbuminemia on outcomes following pancreaticoduodenectomy and outline optimal hypoalbuminemia cut-off values in this population. Methods: The ACS-NSQIP (2016–2021) database was used to extract patients who underwent pancreaticoduodenectomy, comparing those with hypoalbuminemia (< 3.0 g/L) to those with normal albumin. Demographics and 30-day outcomes were compared. Multivariable modeling evaluated factors including hypoalbuminemia to characterize their independent effect on serious complications, and mortality. Optimal albumin cut-offs for serious complications and mortality were evaluated using receiver-operating characteristic curves. Results: We evaluated 25,848 pancreaticoduodenectomy patients with 2712 (10.5%) having preoperative hypoalbuminemia. Patients with hypoalbuminemia were older (68.2 vs. 65.1; p < 0.0001), and were significantly more likely to be ASA class 4 or higher (13.9% vs. 6.7%; p < 0.0001). Patients with hypoalbuminemia had significantly more 30-day complications and after controlling for comorbidities hypoalbuminemia remained a significant independent factor associated with 30-day serious complications (OR 1.80, p < 0.0001) but not mortality (OR 1.37, p = 0.152). Conclusions: Hypoalbuminemia plays a significant role in 30-day morbidity following pancreaticoduodenectomy. Preoperative albumin may serve as a useful marker for risk stratification and optimization. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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