1. ω-Aryloxy Analogs of Prostamides.
- Author
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Vostrikov, N. S., Lobko, I. F., Loza, V. V., and Miftakhov, M. S.
- Subjects
- *
METHYL formate , *ACETIC anhydride , *ACYLATION , *GROUP formation , *ACETYLATION , *DEACETYLATION - Abstract
Acylation of cloprostenol with acetic anhydride in pyridine, followed by treatment of the exhaustive acetylation product with water, gave 9,11,15-triacetoxy derivative whose reaction with 1,1′-carbonyldiimidazole afforded the corresponding imidazolide. The subsequent condensation with 2-aminoethanol and removal of acetate protecting group lead to the formation of N-(2-hydroxyethyl) cloprostenol amide. Analogous N-ethyl amide was synthesized by reaction of cloprostenol methyl ester with aqueous ethylamine. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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