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Your search keyword '"Vulto, A.G."' showing total 1 results
Start Over Author "Vulto, A.G." Topic analgesics, pharmacokinetics
1 results on '"Vulto, A.G."'

1. Postoperative Pain Management in Children following (Adeno)Tonsillectomy: Efficacy, Pharmacokinetics and Tolerability of Paracetamol and Diclofenac.

Author

Peters, J.W.B., Vulto, A.G., Grobee, R., and Meursing, A.E.E.

Subjects
*POSTOPERATIVE pain treatment, *TONSILLECTOMY, *DRUG efficacy, *PHARMACOKINETICS, *DRUG tolerance
Abstract

Concerns exist about the optimal analgesic for postoperative pain management following (adeno)tonsillectomy. Hence, we decided to review the efficacy of paracetamol (acetaminophen) and diclofenac in children aged 3 to 12 years after (adeno)tonsillectomy. Pharmacokinetics and adverse effects of the two agents were also addressed. A MEDLINE search (1966 to 1998), review articles and textbooks were used as data sources. In general, systematic and practice-based research on these drugs for this indication is scarce. Paracetamol 20 mg/kg administered orally, 60 minutes preoperatively, and diclofenac 2 mg/kg administered rectally at induction seem to achieve satisfactory analgesia in the majority of children during the first few hours postoperatively. [ABSTRACT FROM AUTHOR]

Published
1999
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