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The aqueous root extract of the Delphinium denudatum was evaluated for acute oral toxicity and antinociceptive effects in mice. Oral doses up to 14,000 mg/kg did not induce death, some CNS depression was observed and the LD50 was found at 16,100 mg/kg. At the four dose levels used (200-1600 mg/kg, p.o.), D. denudatum extract demonstrated a dose-dependent antinociceptive effect in the thermal and chemical models of analgesia. Pretreatment with naloxone did not alter the analgesic effect of D. denudatum extract suggesting that some mechanism other than opioid is involved in their action. [ABSTRACT FROM AUTHOR]